放疗相关性肠损伤与癌因性疲乏的相关性：简要回顾与述评。
Association of Radiotherapy-Related Intestinal Injury and Cancer-related Fatigue: A Brief Review and Commentary.
机构信息
Assistant Professor, New York University Rory Meyers, College of Nursing, NY, United States.
College of Arts and Sciences, University of South Florida, Tampa, FL, United States.
出版信息
P R Health Sci J. 2021 Mar;40(1):6-11.
Abstract
Radiotherapy treatment-induced intestinal injury and gut microbial perturbation/dysbiosis have been implicated in the pathobiology of cancer-related fatigue. The objective of this brief review was to explore the available evidence of the relationship between intestinal injury and self-reported fatigue, especially among cancer patients. The scientific evidence-including our own-linking gut mucosal barrier dysfunction and gut microbial perturbation/dysbiosis induced by cancer treatment with worsening of cancer related fatigue (perhaps through the gut-brain axis) is limited but promising. Emerging data suggest that lifestyle interventions and the administration of specific probiotics may favorably modulate the gut microbiota and potentially mediate beneficial effects leading to improvements in fatigue.
摘要
放疗治疗引起的肠道损伤和肠道微生物失调/紊乱与癌症相关疲劳的发病机制有关。本综述的目的是探讨肠道损伤与自我报告的疲劳之间的现有证据，特别是在癌症患者中。科学证据——包括我们自己的证据——将癌症治疗引起的肠道黏膜屏障功能障碍和肠道微生物失调/紊乱与癌症相关疲劳的恶化联系起来（可能通过肠道-大脑轴），虽然有限，但很有希望。新出现的数据表明，生活方式干预和特定益生菌的应用可能有利于调节肠道微生物群，并可能通过介导有益的效果来改善疲劳。
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