肠道微生物群失调与直肠癌患者的急性睡眠障碍有关。
Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients.
机构信息
College of Nursing, University of South Florida, Tampa, FL, USA.
College of Nursing, College of Public Health, University of South Florida, Tampa, FL, USA.
出版信息
J Sleep Res. 2020 Jun;29(3):e12915. doi: 10.1111/jsr.12915. Epub 2019 Oct 10.
Abstract
Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52-81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological "gut-brain axis" mechanism may be associated with symptoms of sleep disturbance.
摘要
癌症治疗相关的肠道微生物扰动/失调与睡眠障碍的病理生理学有关；然而，证据有限。18 名新诊断的直肠癌患者（年龄 52-81 岁；男性 10 名）在化疗和放疗期间完成了睡眠障碍问卷，并提供了粪便样本进行 16s RNA 基因测序。计算了描述性统计、Wilcoxon 检验和回归分析。回归分析显示，香农多样性指数是与睡眠障碍相关的重要因素。这项初步工作表明，生物学的“肠-脑轴”机制可能与睡眠障碍的症状有关。
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