Rodrigues Mirelen Moura de Oliveira, Höher Gabriela, Waskow Gabriela, Hutz Mara Helena, Lindenau Juliana Dal-Ri, Petzl-Erler Maria Luiza, Callegari-Jacques Sidia Maria, Almeida Silvana, Fiegenbaum Marilu
Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Programa de Pós-Graduação em Biociências, Porto Alegre, RS, Brazil.
Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Porto Alegre, RS, Brazil.
Genet Mol Biol. 2021 Apr 19;44(2):e20200255. doi: 10.1590/1678-4685-GMB-2020-0255. eCollection 2021.
The study presents comparisons between blood group frequencies beyond ABO and Rh blood systems in Native American populations and previously published data from Brazilian blood donors. The frequencies of Diego (c.2561C>T, rs2285644), Kell (c.578C>T, rs8176058), Duffy (c.125A>G, rs12075, c.1-67T>C, rs2814778) and Kidd (c.838A>G, rs1058396) variants in Kaingang (n=72) and Guarani (n=234) populations from Brazil (1990-2000) were obtained and compared with data from these populations sampled during the 1960s and with individuals of different Brazilian regions. Data showed high frequencies of DI01 and FY01 alleles: 11.8% and 57.6% in Kaingang and 6.8% and 75.7% in Guarani groups, respectively. The main results indicated: (1) reduction in genetic distance over time of Kaingang and Guarani in relation to other Brazilian populations is suggestive of ongoing admixture; (2) significant differences in some frequencies of blood group markers (especially Diego, Kidd and Duffy) in relation to Native Americans and individuals from different geographical regions of Brazil. Our study shows that the frequency of red blood cell polymorphisms in two Native American groups is very different from that of blood donors, when we evaluated blood groups different from ABO and Rh systems, suggesting that a better ethnic characterization of blood unit receptors is necessary.
该研究呈现了美洲原住民群体中ABO和Rh血型系统以外的血型频率与巴西献血者先前公布数据之间的比较。获取了巴西（1990 - 2000年）凯冈族（n = 72）和瓜拉尼族（n = 234）人群中迪戈（c.2561C>T，rs2285644）、凯尔（c.578C>T，rs8176058）、达菲（c.125A>G，rs12075，c.1 - 67T>C，rs2814778）和基德（c.838A>G，rs1058396）变体的频率，并与20世纪60年代从这些人群中采样的数据以及巴西不同地区的个体进行比较。数据显示DI01和FY01等位基因频率较高：在凯冈族中分别为11.8%和57.6%，在瓜拉尼族中分别为6.8%和75.7%。主要结果表明：（1）随着时间推移，凯冈族和瓜拉尼族与其他巴西人群之间的遗传距离减小，这表明正在发生基因混合；（2）与美洲原住民和巴西不同地理区域的个体相比，某些血型标记（尤其是迪戈、基德和达菲）的频率存在显著差异。我们的研究表明，当我们评估ABO和Rh系统以外不同血型时，两个美洲原住民群体中红细胞多态性的频率与献血者的频率非常不同，这表明有必要对血液单位受体进行更好的种族特征描述。
