Department of Biosciences, Università degli Studi di Milano, Milano, Italy; Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milano, Italy.
Department of Biosciences, Università degli Studi di Milano, Milano, Italy.
Neurosci Lett. 2021 Jun 11;755:135900. doi: 10.1016/j.neulet.2021.135900. Epub 2021 Apr 18.
Neurons are the perfect example of cells where microtubules are essential to achieve an extraordinary degree of morphological and functional complexity. Different tubulin isoforms and associated post-translational modifications are the basis to establish the diversity in biochemical and biophysical properties of microtubules including their stability and the control of intracellular transport. Acetylation is one of the key tubulin modifications and it can influence important structural, mechanical and biological traits of the microtubule network. Here, we present the emerging evidence for the essential role of microtubule acetylation in the control of neuronal and glial function in healthy and degenerative conditions. In particular, we discuss the pathogenic role of tubulin acetylation in neurodegenerative disorders and focus on Parkinson's disease. We also provide a critical analysis about the possibility to target tubulin acetylation as a novel therapeutic intervention for neuroprotective strategies.
神经元是微管对于实现高度形态和功能复杂性至关重要的完美细胞范例。不同的微管蛋白异构体和相关的翻译后修饰是建立微管生化和生物物理特性多样性的基础，包括其稳定性和细胞内运输的控制。乙酰化是微管蛋白的关键修饰之一，它可以影响微管网络的重要结构、力学和生物学特性。在这里，我们提出了越来越多的证据，证明微管乙酰化在控制健康和退行性条件下神经元和神经胶质功能方面的重要作用。特别是，我们讨论了微管乙酰化在神经退行性疾病中的致病作用，并重点关注帕金森病。我们还对将微管乙酰化作为神经保护策略的新的治疗干预靶点的可能性进行了批判性分析。
