Laboratory of Neuroscience, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea; Comparative Medicine Disease Research Center, Seoul National University, Seoul, South Korea.
Laboratory of Neuroscience, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea; BK21 Four Future Veterinary Medicine Leading Education & Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea.
Mol Cells. 2024 Oct;47(10):100111. doi: 10.1016/j.mocell.2024.100111. Epub 2024 Sep 10.
Microtubules are core components of the neuronal cytoskeleton, providing structural support for the complex cytoarchitecture of neurons and serving as tracks for long-distance transport. The properties and functions of neuronal microtubules are controlled by tubulin isoforms and a variety of post-translational modifications, collectively known as the "tubulin code." The tubulin code exerts direct control over the intrinsic properties of neuronal microtubules and regulates the repertoire of proteins that read the code, which in turn, has a significant impact on microtubule stability and dynamics. Here, we review progress in the understanding of the tubulin code in the nervous system, with a particular focus on tubulin post-translational modifications that have been proposed as potential contributors to the development and maintenance of the mammalian nervous system. Furthermore, we also discuss the potential links between disruptions in the tubulin code and neurological disorders, including neurodevelopmental abnormalities and neurodegenerative diseases.
微管是神经元细胞骨架的核心成分，为神经元复杂的细胞结构提供结构支持，并作为远距离运输的轨道。神经元微管的性质和功能受微管蛋白异构体和多种翻译后修饰的控制，统称为“微管密码”。微管密码直接控制神经元微管的固有特性，并调节读取密码的蛋白质的种类，这反过来又对微管的稳定性和动态性产生重大影响。在这里，我们回顾了神经系统中对微管密码的理解进展，特别关注了被认为是哺乳动物神经系统发育和维持的潜在贡献者的微管翻译后修饰。此外，我们还讨论了微管密码的破坏与神经紊乱之间的潜在联系，包括神经发育异常和神经退行性疾病。
