Department of Radiological Science, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Department of Radiological Science, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Seizure. 2021 May;88:130-137. doi: 10.1016/j.seizure.2021.04.007. Epub 2021 Apr 18.
To assess the association between hypometabolic extension of F-fluorodeoxyglucose positron emission tomography and diffusion tensor imaging indices, including mean diffusivity (MD) and fractional anisotropy (FA), in hippocampal sclerosis (HS).
Thirty-six unilateral HS were retrospectively selected and stratified into two groups: broad and localized hypometabolic groups (hypometabolism beyond [n = 26] and within the temporal lobe [n = 10]). Forty-one pairs of gray matter (GM) regions of interest (ROIs) were segmented using FreeSurfer software. The GM ROIs were applied to MD maps, and median MD values within each ROI were compared between hemispheres ipsilateral and contralateral to HS using a mixed effect model. Tract-Based Spatial Statistics (TBSS) was used to evaluate FA of white matter (WM) tracts between hemispheres ipsilateral and contralateral to HS. Disease laterality was controlled for.
The MD values in the thalamus, caudate, hippocampus, amygdala, superior frontal gyrus, middle and inferior temporal gyrus, temporal pole, and isthmus cingulate gyrus were significantly higher in the HS side than the contralateral side for the broad hypometabolic group. Those in the amygdala and superior temporal sulcus were significantly higher in the HS side than the contralateral side for the localized group. The TBSS analyses showed significantly decreased FA in the WM tracts of the temporal and frontal lobes for the broad hypometabolic group, while no tracts showed significant differences for the localized group.
The hypometabolic extension for HS was associated with the abnormalities of MD and FA in GM and WM, respectively, with more widespread microstructural alterations for broad hypometabolic HS.
评估 F-氟脱氧葡萄糖正电子发射断层扫描（F-fluorodeoxyglucose positron emission tomography，FDG-PET）代谢低下延伸与弥散张量成像（diffusion tensor imaging，DTI）指标（包括平均弥散度（mean diffusivity，MD）和各向异性分数（fractional anisotropy，FA））之间的相关性，以评估海马硬化（hippocampal sclerosis，HS）中的这种相关性。
回顾性选择 36 例单侧 HS 患者，并将其分为两组：广泛代谢低下组（代谢低下范围超出[ n = 26]颞叶[ n = 10]）和局灶性代谢低下组（代谢低下范围局限于颞叶内[ n = 10]）。使用 FreeSurfer 软件对 41 对灰质（gray matter，GM）感兴趣区（region of interest，ROI）进行分割。将 GM ROI 应用于 MD 图谱，使用混合效应模型比较 HS 对侧和同侧半球的每个 ROI 内的 MD 中位数。使用基于束流的空间统计学（tract-based spatial statistics，TBSS）评估 HS 对侧和同侧半球白质（white matter，WM）束的 FA。控制疾病的偏侧性。
广泛代谢低下组的丘脑、尾状核、海马、杏仁核、额上回、中颞回和下颞回、颞极和扣带回峡部的 MD 值在 HS 侧显著高于对侧。局灶性组的杏仁核和上颞回的 MD 值在 HS 侧显著高于对侧。TBSS 分析显示，广泛代谢低下组的颞叶和额叶 WM 束的 FA 显著降低，而局灶性组无明显差异。
HS 的代谢低下延伸与 GM 和 WM 的 MD 和 FA 异常分别相关，广泛代谢低下 HS 的微观结构改变更为广泛。
