Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Krakow Centre for Medical Research and Technologies, John Paul II Hospital, Krakow, Poland.
Semin Thromb Hemost. 2021 Jul;47(5):480-489. doi: 10.1055/s-0041-1725094. Epub 2021 Apr 20.
Fibrinolysis is of paramount importance in maintaining or regaining the patency of veins and pulmonary arteries obstructed by thrombi. Growing experimental and clinical evidence indicates that impaired fibrinolysis mediated by multiple complex mechanisms is involved in venous thromboembolism (VTE). Global plasma fibrin clot lysis markers, especially clot lysis time, have been reported to predict recurrent deep-vein thrombosis and pulmonary embolism. The current overview summarizes available data linking fibrinolysis to VTE and its long-term sequelae.
纤维蛋白溶解在维持或恢复被血栓阻塞的静脉和肺动脉的通畅方面至关重要。越来越多的实验和临床证据表明，多种复杂机制介导的纤溶受损与静脉血栓栓塞症（VTE）有关。已报道全球血浆纤维蛋白凝块溶解标志物，尤其是凝块溶解时间，可预测复发性深静脉血栓形成和肺栓塞。本综述总结了将纤溶与 VTE 及其长期后果联系起来的现有数据。
