父亲吸烟与自闭症谱系障碍的可能性之间的产前暴露关系。
Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder.
机构信息
University of California, San Francisco, USA.
Dankook University, Korea.
出版信息
Autism. 2021 Oct;25(7):1946-1959. doi: 10.1177/13623613211007319. Epub 2021 Apr 20.
Abstract
Genetics, (including mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention. This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk. Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring.
摘要
遗传学（包括突变）、环境因素（包括有毒物质暴露）及其相互作用影响自闭症谱系障碍的病因。由于生物学上的合理性、高患病率和潜在的干预措施，父亲吸烟是自闭症谱系障碍的一个候选风险因素。这项原始研究及其复制证实，父亲因素可以为他们的后代的自闭症谱系障碍风险做出重大贡献。它特别表明，父亲在怀孕前后吸烟都会显著增加自闭症谱系障碍的风险。吸烟预防，特别是在怀孕计划中，可能会降低后代患自闭症谱系障碍的风险。
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