Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan/ Department of Biochemistry, Liaquat National Medical College, Karachi, Pakistan.
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Pak J Pharm Sci. 2020 Nov;33(6(Supplementary)):2785-2791.
Exposure to cadmium has been extensively increased due to its usage in modern daily life. Inside the human body it induces deteriorating effects in every vital organ including brain. Oxidative stress has been widely implicated in neurotoxicity induced by cadmium exposure. Consumption of dietary source of exogenous antioxidants is one of the recommended ways to extenuate heavy metal-induced oxidative stress. The potential of nuts against heavy-metal induced neurotoxicity has not been investigated earlier. This study was, therefore, conducted to find out the antioxidant ability of almond and walnut in the prevention of cadmium-induced oxidative stress. Rats were treated with nuts (400 mg/kg) daily for 28 days whereas, cadmium (50 mg/kg) was given once in a week. Brain function was monitored in terms of memory performance using Morris water maze and elevated plus maze. Moreover, oxidative stress status was also evaluated. Results showed that weekly exposure of cadmium significantly reduced %memory retention, increased lipid per oxidation and inhibited antioxidant enzymes activity. When nuts supplemented rats were monitored for these parameters, it was observed that almond and walnut have a great potential to reduce cadmium-induced neurotoxicity as evident by decreased oxidative stress and improved memory function in cadmium intoxicated rats.
由于镉在现代日常生活中的广泛应用，其暴露量已大大增加。在人体内，它会对包括大脑在内的每个重要器官造成恶化影响。氧化应激广泛涉及镉暴露引起的神经毒性。食用膳食来源的外源性抗氧化剂是减轻重金属诱导的氧化应激的推荐方法之一。坚果对重金属诱导的神经毒性的潜在作用以前尚未得到研究。因此，本研究旨在发现杏仁和核桃的抗氧化能力，以预防镉诱导的氧化应激。大鼠每天用坚果（400mg/kg）处理 28 天，而每周给予一次镉（50mg/kg）。使用 Morris 水迷宫和高架十字迷宫监测大脑功能，以评估记忆表现。此外，还评估了氧化应激状态。结果表明，每周接触镉会显著降低记忆保留率，增加脂质过氧化作用，并抑制抗氧化酶的活性。当监测补充坚果的大鼠时，观察到杏仁和核桃具有很大的潜力，可以减轻镉引起的神经毒性，这可以通过降低氧化应激和改善镉中毒大鼠的记忆功能来证明。
