Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan.
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Plant Foods Hum Nutr. 2018 Mar;73(1):7-12. doi: 10.1007/s11130-018-0655-4.
Scopolamine, an anti-muscarinic agent, has been shown to induce amnesia and oxidative stress similar to that observed in the older age. The present study was designed to determine the relationship between the oxidative status and memory improvement in scopolamine injected rats pre-administered with almonds. Rats (n = 8) in the almond group were administered orally with 400 mg/kg almond suspension for 28 days daily before the intraperitoneal injection of scopolamine (0.5 mg/kg). Passive avoidance task (PAT) was used to assess memory function at the end of treatment. The present study revealed that scopolamine injection significantly impaired the memory function in rats pre-treated with saline which was accompanied by increased oxidative stress as evident by increased brain malondialdehyde (MDA) levels and reduced activities of antioxidant enzymes as compared to healthy controls. Pre-treatment with almond significantly ameliorated scopolamine-induced oxidative stress and memory dysfunction. These findings suggest that dietary supplementation with almonds may have a beneficial effect in reducing the risk of oxidative stress-induced memory loss and delaying or preventing the onset of age-related memory impairment.
东莨菪碱是一种抗毒蕈碱药物，已被证明可诱导与老年时观察到的相似的健忘症和氧化应激。本研究旨在确定氧化状态与预先给予杏仁的东莨菪碱注射大鼠的记忆改善之间的关系。杏仁组的大鼠（n = 8）在腹腔注射东莨菪碱（0.5 mg/kg）之前，每日口服给予 400 mg/kg 杏仁混悬液 28 天。在治疗结束时，使用被动回避任务（PAT）评估记忆功能。本研究表明，与健康对照组相比，盐水预处理的东莨菪碱注射显着损害了大鼠的记忆功能，并且伴随着氧化应激的增加，表现为脑丙二醛（MDA）水平升高和抗氧化酶活性降低。杏仁预处理可显著改善东莨菪碱诱导的氧化应激和记忆功能障碍。这些发现表明，杏仁的饮食补充可能具有减轻氧化应激诱导的记忆丧失风险以及延迟或预防与年龄相关的记忆障碍发生的有益作用。
