College of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Faculty of Pharmacy, Department of Pharmacology, The University of Lahore, Lahore, Pakistan.
Pak J Pharm Sci. 2020 Nov;33(6(Supplementary)):2823-2830.
Lactucaserriola (L. serriola), commonly known asprickly lettuce, is an annual and biennial herb. The plant is traditionally used as sedative, hypnotic, cough suppressant, expectorant, purgative, diuretic, vasorelaxant, demulcent, antiseptic and antispasmodic. Aim of present study was to evaluate protective effect of L. serriola in paracetamol-induced hepatotoxicity. Silymarin was used as a standard drug. Hepatoprotective effect of extract was determined by liver biochemical markers, anti-oxidant enzymes and blood lipid profile. Methanolic extract was found to be the most potent in in-vitro antioxidant assays and used for further studies. Treatment with paracetamol increased the level of hepatic biomarkers, blood lipid profile and decreased anti-oxidant enzyme levels. Pre-treatment with Lactuca serriola caused restoration of hepatic biomarkers, blood lipid profile and antioxidant enzymes. FTIR represented that L. serriola contains hydroxyl (-OH), carboxylic acid (C=O) and alkene (C=C) groups. HPLC analysis showed presence of polyphenolic compounds in the methanolic extract of L. serriola. It is concluded that the methanolic extract of Lactuca serriola possesses hepatoprotective potential that might be linked to the presence of polyphenolic compounds and their anti-oxidant activities.
乳苣（L. serriola），俗称刺莴苣，是一种一年生和二年生草本植物。该植物传统上被用作镇静剂、催眠剂、止咳药、祛痰药、泻药、利尿剂、血管松弛剂、缓和剂、防腐剂和抗痉挛药。本研究旨在评估乳苣在对乙酰氨基酚诱导的肝毒性中的保护作用。水飞蓟素被用作标准药物。通过肝生化标志物、抗氧化酶和血脂谱来确定提取物的保肝作用。发现乳苣的甲醇提取物在体外抗氧化测定中最有效，并用于进一步研究。对乙酰氨基酚的治疗增加了肝生物标志物、血脂谱和降低了抗氧化酶水平。乳苣预处理可恢复肝生物标志物、血脂谱和抗氧化酶。FTIR 表明乳苣含有羟基（-OH）、羧酸（C=O）和烯烃（C=C）基团。HPLC 分析表明乳苣甲醇提取物中存在多酚类化合物。综上所述，乳苣的甲醇提取物具有保肝作用，这可能与多酚类化合物的存在及其抗氧化活性有关。
