Chen Zhijun, Zhu Siyuan, Liu Meihua, Tang Genhua, Zhong Zhiying, Lu LunBin
The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine.
Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Medicine (Baltimore). 2021 Apr 23;100(16):e25385. doi: 10.1097/MD.0000000000025385.
Senile hypotension refers to those whose blood pressure (BP) is lower than 90/60 mm Hg. The consequences can not only cause insufficient cardio-cerebral perfusion, but severe cases may also cause angina pectoris and stroke. At present, Western medicine has no ideal therapeutic drugs for senile hypotension. The aim of this systematic review is to assess the effectiveness and safety of traditional Chinese medicine (TCM) therapy for senile hypotension.
Two reviewers will electronically search the following databases: the Cochrane Central Register of Controlled Trials; PubMed; EMBASE; China National Knowledge Infrastructure; Chinese Biomedical Literature Database; Chinese Scientific Journal Database (VIP database); and Wan-Fang Database from the inception, without restriction of publication status and languages. Additional searching including researches in progress, the reference lists and the citation lists of identified publications. Study selection, data extraction, and assessment of study quality will be performed independently by 2 reviewers. If it is appropriate for a meta-analysis, RevMan 5.4 statistical software will be used; otherwise, a descriptive analysis will be conducted. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. The results will be presented as risk ratio (RR) with 95% confidence intervals (CIs) for dichotomous data and weight mean difference (WMD) or standard mean difference 95% CIs for continuous data.
This study will provide a comprehensive review of the available evidence for the treatment of TCM with senile hypotension.
The conclusions of our study will provide an evidence to judge whether TCM is an effective and safe intervention for patients with senile hypotension.
This systematic review will be disseminated in a peer-reviewed journal or presented at relevant conferences. It is not necessary for a formal ethical approval because the data are not individualized.
INPLASY2020110091.
老年低血压是指血压低于90/60 mmHg的人群。其后果不仅会导致心脑灌注不足，严重时还可能引发心绞痛和中风。目前，西医对于老年低血压尚无理想的治疗药物。本系统评价的目的是评估中医治疗老年低血压的有效性和安全性。
两名研究者将通过电子检索以下数据库：Cochrane对照试验中心注册库；PubMed；EMBASE；中国知网；中国生物医学文献数据库；中文科技期刊数据库（维普数据库）；以及万方数据库，检索起始时间不限，不限制出版状态和语言。额外检索包括正在进行的研究、已识别出版物的参考文献列表和被引文献列表。由两名研究者独立进行研究选择、数据提取和研究质量评估。若适合进行Meta分析，将使用RevMan 5.4统计软件；否则，将进行描述性分析。根据异质性检验，采用固定效应模型或随机效应模型对数据进行合并。结果将以二分类数据的风险比（RR）及其95%置信区间（CI）和连续性数据的加权均数差（WMD）或标准化均数差及其95%CI的形式呈现。
本研究将全面综述中医治疗老年低血压的现有证据。
我们的研究结论将为判断中医是否是治疗老年低血压患者的有效且安全的干预措施提供依据。
本系统评价将在同行评审期刊上发表或在相关会议上展示。由于数据不涉及个体信息，无需正式伦理批准。
INPLASY2020110091。
