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中医外治法治疗儿童功能性消化不良的系统评价和网络Meta 分析方案。

External treatment of traditional Chinese medicine for functional dyspepsia in children: Protocol for a systematic review and network meta-analysis.

机构信息

Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, China.

Department of Endocrinology, The Second Affiliated Hospital of Changchun University of Chinese Medicine (Changchun Hospital of Chinese Medicine), Changchun, China.

出版信息

Medicine (Baltimore). 2022 Oct 28;101(43):e31597. doi: 10.1097/MD.0000000000031597.


DOI:10.1097/MD.0000000000031597
PMID:36316912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9622658/
Abstract

BACKGROUND: Functional dyspepsia (FD) is a common digestive system disease in pediatrics, usually affects normal growth and increases health care expenditure. Many investigations have demonstrated that external treatment of traditional Chinese medicine (TCM) has certain advantages in the treatment of FD children, but the effectiveness, safety, and advantages of various methods have not been confirmed by high-quality meta-analyses. This study will conduct a systematic review and network meta-analysis to evaluate the differences and effectiveness in external treatments of TCM, in order to provide a reference for further clinical treatment for FD in children. METHODS: Nine electronic databases, including PubMed, Medline, Embase, Web of Science, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, Wan-Fang Database and one clinical trial register platforms: ClinicalTrials.gov (www.ClinicalTrials.gov/) will be searched using English and Chinese search strategies. All eligible studies are randomized controlled trials of TCM external treatment for FD in children, published on or before July 20, 2022. The screening process will be developed by 2 independent authors, and network meta-analysis will be performed with RevMan (V5.3) software. RESULTS: This study will provide a high-quality synthesis to assess the effectiveness and safety on the external treatment of TCM for children with FD. CONCLUSION: The results of this study will provide evidence to judge whether the external treatment of TCM are effective interventions for children with FD. ETHICS AND DISSEMINATION: The results of this meta-analysis and meta-regression will be disseminated through publication in a peer-reviewed journal and presented at a relevant conference. The information used in the network meta-analysis does not contain individual patient data. Therefore, ethical approval was not required. PROSPERO REGISTRATION NUMBER: CRD42022360429.

摘要

背景:功能性消化不良(FD)是儿科常见的消化系统疾病,常影响正常生长发育,增加医疗保健支出。许多研究表明,中医(TCM)的外部治疗在 FD 儿童的治疗中有一定优势,但各种方法的有效性、安全性和优势尚未通过高质量的荟萃分析得到证实。本研究将进行系统评价和网络荟萃分析,以评估 TCM 外部治疗的差异和效果,为进一步为儿童 FD 提供临床治疗参考。

方法:将检索 9 个电子数据库,包括 PubMed、Medline、Embase、Web of Science、Cochrane 中央对照试验注册库、中国国家知识基础设施、中国生物医学文献数据库、中国科学期刊数据库、万方数据库和一个临床试验注册平台:ClinicalTrials.gov(www.ClinicalTrials.gov/),检索时间截至 2022 年 7 月 20 日,检索策略将同时使用英文和中文。所有符合条件的研究均为 TCM 外部治疗 FD 儿童的随机对照试验。筛选过程将由 2 位独立作者进行,采用 RevMan(V5.3)软件进行网络荟萃分析。

结果:本研究将提供高质量的综合评价,以评估 TCM 对 FD 儿童的外部治疗的有效性和安全性。

结论:本研究的结果将为判断 TCM 外部治疗是否对 FD 儿童有效干预提供依据。

伦理与传播:本荟萃分析和荟萃回归的结果将通过在同行评议期刊上发表和在相关会议上展示来传播。网络荟萃分析中使用的信息不包含个体患者数据。因此,不需要伦理批准。

PROSPERO 注册号:CRD42022360429。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36e7/9622658/8aca665e8514/medi-101-e31597-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36e7/9622658/8aca665e8514/medi-101-e31597-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36e7/9622658/8aca665e8514/medi-101-e31597-g001.jpg

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