与类风湿关节炎以外的其他疾病相关的低水平抗环瓜氨酸肽（CCP）3.1。
Low levels of anti-cyclic citrullinated peptide (CCP) 3.1 associated with diseases other than rheumatoid arthritis.
机构信息
Department of Internal Medicine.
Cedars-Sinai Medical Center, Division of Rheumatology, Los Angeles, CA.
出版信息
Medicine (Baltimore). 2021 Apr 23;100(16):e25558. doi: 10.1097/MD.0000000000025558.
Our aim was to investigate the newest generation anti-cyclic citrullinated peptide (CCP) antibody 3.1 assay in diagnosing rheumatoid arthritis (RA) compared with other autoimmune and non-autoimmune diseases. We performed a retrospective observational chart review of patients with a positive CCP level over a one-year period at a single academic institution and assessed the associated diagnoses after at least six-months of follow-up. Of the 281 CCP positive patients during that period, 48% had a diagnosis of RA. The positive predictive value of RA in patients with a high CCP 3.1 assay was 0.619 compared to 0.248 with a low positive CCP 3.1 assay (P < .0001). Overall, there was a lower than expected positive predictive value of CCP 3.1 level with an RA diagnosis, though the likelihood of having an RA diagnosis was higher with a higher CCP level.
我们的目的是研究新一代抗环瓜氨酸肽（CCP）抗体 3.1 检测在诊断类风湿关节炎（RA）方面与其他自身免疫性和非自身免疫性疾病的比较。我们对一家学术机构在一年内 CCP 水平阳性的患者进行了回顾性观察性图表审查，并在至少 6 个月的随访后评估了相关诊断。在此期间，281 名 CCP 阳性患者中，48%的患者被诊断为 RA。与低阳性 CCP 3.1 检测（P<0.0001）相比，高 CCP 3.1 检测的 RA 患者阳性预测值为 0.619。总体而言，RA 诊断的 CCP 3.1 水平阳性预测值低于预期，但 CCP 水平越高，RA 诊断的可能性越大。
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