Department of Internal Medicine, Hospital Puerta de Hierro-Majadahonda, Madrid.
Internal Medicine Lab, Research Institute Segovia de Arana-Puerta de Hierro-Majadahonda.
Medicine (Baltimore). 2021 Apr 23;100(16):e25634. doi: 10.1097/MD.0000000000025634.
Spain is one of the European countries most largely affected by COVID-19, being Madrid the epicenter. A good knowledge of the main features of hospitalized patients during the complete lockdown should improve the management of new COVID-19 surges.All patients hospitalized at one large tertiary hospital in Madrid for suspected COVID-19 pneumonia from March 1 to May 31 were retrospectively identified.A total of 1752 patients were admitted with suspected pneumonia due to SARS-CoV-2 infection during the 3-month study period. The peak of daily admissions (n = 84) was reached on March 24, whereas the maximal cumulative number of hospitalized patients (n = 626) occurred on March 30. Overall, 85.3% had a positive PCR test for SARS-CoV-2 at least once during admission. Their median age was 65 (54-77) and 59.9% were male. The median length of hospitalization was of 7 (4-13) days. Roughly 6.5% were admitted at the intensive care unit.Death occurred in 242 (13.8%). Overall, 75% of deaths occurred in patients older than 75 years-old. It was 38.2% in patients hospitalized older than 80 years-old versus 2.2% in patients younger than 60 years-old (p < 0.001). Up to 94 (38.8%) of deceased patients had been transferred from nursing homes. The median Charlson co-morbidity score was 6 in deceased patients.The in-hospital mortality rate during the first wave of COVID-19 in Madrid was 14%. It was largely driven by older age, the presence of underlying chronic conditions (≥2) and living at nursing homes.
西班牙是受 COVID-19 影响最严重的欧洲国家之一，马德里是疫情中心。充分了解完全封锁期间住院患者的主要特征，应能改善对新一波 COVID-19 疫情的管理。
在马德里的一家大型三级医院，回顾性地确定了 3 月 1 日至 5 月 31 日期间因疑似 COVID-19 肺炎而住院的所有患者。在 3 个月的研究期间，共有 1752 名因 SARS-CoV-2 感染而疑似肺炎的患者入院。每日入院人数（n=84）的高峰出现在 3 月 24 日，而住院患者的最大累计人数（n=626）出现在 3 月 30 日。总体而言，85.3%的患者在住院期间至少有一次 SARS-CoV-2 PCR 检测呈阳性。他们的中位年龄为 65 岁（54-77 岁），59.9%为男性。住院中位数为 7 天（4-13 天）。大约 6.5%的患者被收入重症监护病房。242 人（13.8%）死亡。总体而言，75%的死亡发生在 75 岁以上的患者中。80 岁以上患者的死亡率为 38.2%，而 60 岁以下患者的死亡率为 2.2%（p<0.001）。多达 94 名（38.8%）死亡患者是从疗养院转来的。死亡患者的 Charlson 合并症评分中位数为 6 分。
马德里 COVID-19 第一波疫情的院内死亡率为 14%。它主要是由年龄较大、存在潜在慢性疾病（≥2 种）和居住在疗养院推动的。
