Obstetrics Department.
Urology Department.
Medicine (Baltimore). 2021 Apr 23;100(16):e25646. doi: 10.1097/MD.0000000000025646.
To determine the association of betatrophin amounts with 25-(OH)D levels in gestational diabetes mellitus (GDM) patients, and to provide new targets for the prevention and treatment of GDM.This study included 40 GDM patients (GDM group) and 37 healthy pregnant women (control group). Betatrophin, 25-(OH)D, fasting blood glucose (FBG), HbA1c, hsCRP, and FINS levels in peripheral blood, as well as betatrophin and 25-(OH)D amounts in cord blood, were measured. Then, associations of betatrophin levels with 25-(OH)D amounts and other indexes were determined.Maternal (P = .011) and cord (P = .022) blood betatrophin levels were significantly lower in the GDM group compared with control group. Cord blood betatrophin levels were higher compared with maternal blood amounts in both the GDM and control groups (both P = .000). Serum betatrophin levels were positively associated with 25-(OH)D levels (r = 0.677, P = .000), but negatively associated with hsCRP (r = -0.335, P = .037) and HOMA-IR (r = -0.346, P = .031) levels in the GDM group. Fetal weight was higher in the GDM group compared with control group (P = .023), and negatively associated with cord blood betatrophin amounts in the GDM group (r = -0.342, P = .031). However, cord blood betatrophin levels were not significantly associated with body length, Apgar score, and cord blood 25-(OH)D levels in the GDM group (all P > .05).Serum betatrophin and 25-(OH) D levels were positively associated in women with GDM, and both significantly lower compared with control values. Fetal weight was higher in the GDM group and associated with cord blood betatrophin. These findings provide insights into developing new predictive biomarkers or therapeutic targets for GDM.
为了确定 betatrophin 量与妊娠糖尿病（GDM）患者 25-（OH）D 水平之间的关联，并为 GDM 的预防和治疗提供新的靶点。本研究纳入了 40 例 GDM 患者（GDM 组）和 37 例健康孕妇（对照组）。检测外周血中的 betatrophin、25-（OH）D、空腹血糖（FBG）、HbA1c、hsCRP 和 FINS 水平，以及脐带血中的 betatrophin 和 25-（OH）D 水平。然后，确定 betatrophin 水平与 25-（OH）D 量和其他指标的相关性。与对照组相比，GDM 组产妇（P=0.011）和脐带血（P=0.022）的 betatrophin 水平明显降低。GDM 和对照组的脐带血 betatrophin 水平均高于母体血水平（均 P=0.000）。血清 betatrophin 水平与 25-（OH）D 水平呈正相关（r=0.677，P=0.000），但与 GDM 组的 hsCRP（r=-0.335，P=0.037）和 HOMA-IR（r=-0.346，P=0.031）水平呈负相关。与对照组相比，GDM 组胎儿体重较高（P=0.023），且与 GDM 组脐带血 betatrophin 量呈负相关（r=-0.342，P=0.031）。然而，GDM 组脐带血 betatrophin 水平与胎儿身长、阿普加评分和脐带血 25-（OH）D 水平无显著相关性（均 P＞0.05）。GDM 妇女血清 betatrophin 和 25-（OH）D 水平呈正相关，且均明显低于对照组。GDM 组胎儿体重较高，与脐带血 betatrophin 相关。这些发现为开发新的预测性生物标志物或 GDM 的治疗靶点提供了新的思路。
