Küçükoğlu Keser Merve, Şahin Dilek, Yalçın Sıddika Songül
Department of Pediatrics, Ankara Bilkent City Hospital, Ankara 06800, Turkey.
Department of Social Pediatrics, Institute of Child Health, Hacettepe University, Ankara 06100, Turkey.
Nutrients. 2024 Dec 16;16(24):4334. doi: 10.3390/nu16244334.
BACKGROUND/OBJECTIVES: The prevalence of gestational diabetes mellitus (GDM) is increasing, and GDM poses health risks for both mothers and newborns. This study investigated the association between GDM and two biomarkers, osteopontin (OPN) and betatrophin (ANGPTL8).
This study involved face-to-face interviews with 165 participants-81 in the GDM group and 84 in the control group-to gather maternal-newborn data. Maternal serum OPN levels, along with cord serum OPN and ANGPTL8 levels, were measured at birth. OPN levels in breast milk were also measured between postnatal days 10-15. Statistical analysis included Student's t-test for comparing biomarker levels, chi-square tests for GDM incidence across OPN quartile levels, multiple logistic regression for assessing GDM frequency by OPN quartile levels, and the Pearson correlation coefficient to explore relationships between biomarker levels and maternal-newborn characteristics.
No significant differences in cord OPN or ANGPTL8 levels were detected between the groups. However, the OPN levels in maternal serum and breast milk were greater in the GDM group than in the control group. We found an association between increasing maternal serum and breast milk OPN levels in quartile groups and the risk of GDM. Additionally, there was a moderate correlation between cord OPN and both maternal serum OPN (r = 0.45) and breast milk OPN (r = 0.43).
The differences in OPN levels between the GDM and control groups suggest that OPN may reflect metabolic changes associated with GDM, possibly as a consequence of the condition itself or its treatment. Further research is necessary to validate these findings and uncover the underlying mechanisms involved.
背景/目的：妊娠期糖尿病（GDM）的患病率正在上升，且GDM对母亲和新生儿均构成健康风险。本研究调查了GDM与两种生物标志物骨桥蛋白（OPN）和β-促胰岛素分泌素（ANGPTL8）之间的关联。
本研究对165名参与者进行了面对面访谈，其中GDM组81人，对照组84人，以收集母婴数据。在出生时测量母亲血清OPN水平，以及脐带血清OPN和ANGPTL8水平。还在产后第10 - 15天测量母乳中的OPN水平。统计分析包括用于比较生物标志物水平的学生t检验、用于跨OPN四分位数水平的GDM发病率的卡方检验、用于按OPN四分位数水平评估GDM频率的多元逻辑回归，以及用于探索生物标志物水平与母婴特征之间关系的Pearson相关系数。
两组之间脐带OPN或ANGPTL8水平未检测到显著差异。然而，GDM组母亲血清和母乳中的OPN水平高于对照组。我们发现四分位数组中母亲血清和母乳OPN水平升高与GDM风险之间存在关联。此外，脐带OPN与母亲血清OPN（r = 0.45）和母乳OPN（r = 0.43）之间存在中度相关性。
GDM组和对照组之间OPN水平的差异表明，OPN可能反映了与GDM相关的代谢变化，这可能是该疾病本身或其治疗的结果。有必要进行进一步研究以验证这些发现并揭示其中的潜在机制。
