Green S T, Ng J P, Chan-Lam D
University of Glasgow Department of Materia Medica, Stobhill General Hospital.
Scott Med J. 1988 Feb;33(1):213-4. doi: 10.1177/003693308803300112.
Two classical autoimmune polyendocrine deficiency syndromes with heritable tendencies are described, Type 1 diabetes mellitus being associated with the Type 2 polyendocrine deficiency syndrome (Schmidt's syndrome). A man with Type 1 diabetes mellitus is described who developed an unusual combination of five autoimmune conditions (myasthenia gravis, Addisonian pernicious anaemia, adrenalitis and thyroiditis) which did not fit into the Type 1 or Type 2 classical polyendocrine deficiency syndromes. This suggests that the autoantibody, biochemical and haematological screening of affected individuals and their relatives should be extended to anticipate a wider range of potential autoimmune conditions.
本文描述了两种具有遗传倾向的经典自身免疫性多内分泌腺功能减退综合征，1型糖尿病与2型多内分泌腺功能减退综合征（施密特综合征）相关。文中描述了一名患有1型糖尿病的男性，他出现了五种自身免疫性疾病（重症肌无力、阿狄森恶性贫血、肾上腺炎和甲状腺炎）的不寻常组合，这些疾病并不符合1型或2型经典多内分泌腺功能减退综合征。这表明，应对受影响个体及其亲属进行自身抗体、生化和血液学筛查，以预测更广泛的潜在自身免疫性疾病。
