自组装氧化铁纳米簇用于光热介导的协同化学/化学动力学治疗。
Self-Assembly Iron Oxide Nanoclusters for Photothermal-Mediated Synergistic Chemo/Chemodynamic Therapy.
机构信息
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
出版信息
J Immunol Res. 2021 Apr 7;2021:9958239. doi: 10.1155/2021/9958239. eCollection 2021.
METHODS
Superparamagnetic iron oxide nanoclusters (SPIOCs) were located within the core, which resulted in high photothermal conversion and outstanding generation of reactive oxygen species (ROS). The shell consisted of a human serum albumin- (HSA-) paclitaxel (PTX) layer, which extended the blood circulation time and ensured the effectiveness of the chemotherapy. Arg-Gly-Asp peptides (RGD) were linked to the naked cysteine moieties in HSA to promote the specific targeting of human glioma U87 cells by integrins. Continuous near-infrared light irradiation triggered and promoted the synergistic chemo/CDT therapy through the photothermal effect.
RESULTS
Our SPIOCs@HSA-RGD nanoplatform showed well biocompatibility and could target glioma specifically. Photothermal conversion and ROS burst were detected after continuous 808 nm light irradiation, and a significant antitumor effect was achieved.
CONCLUSION
Experimental in vitro and in vivo evaluations showed that our photothermal-mediated chemo/CDT therapy could efficiently inhibit tumor growth and is therefore promising for cancer therapy.
方法
超顺磁性氧化铁纳米团簇（SPIOCs）位于核心部位，这导致了高的光热转换和活性氧物质（ROS）的出色生成。外壳由人血清白蛋白-（HSA-）紫杉醇（PTX）层组成，这延长了血液循环时间并确保了化疗的有效性。精氨酸-甘氨酸-天冬氨酸肽（RGD）被连接到 HSA 中的裸露半胱氨酸部分，以通过整合素促进人神经胶质瘤 U87 细胞的特异性靶向。连续近红外光照射通过光热效应触发并促进协同化疗/光动力治疗。
结果
我们的 SPIOCs@HSA-RGD 纳米平台表现出良好的生物相容性并且可以特异性地靶向神经胶质瘤。在连续的 808nm 光照射后检测到光热转换和 ROS 爆发，并实现了显著的抗肿瘤效果。
结论
体外和体内实验评估表明，我们的光热介导的化疗/光动力治疗可以有效地抑制肿瘤生长，因此有望用于癌症治疗。
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