Ding Ying, Liu Weimin, Wu Jiasheng, Zheng Xiuli, Ge Jiechao, Ren Haohui, Zhang Wenjun, Lee Chun-Sing, Wang Pengfei
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Chem Asian J. 2021 May 17;16(10):1221-1224. doi: 10.1002/asia.202100205. Epub 2021 Apr 21.
Peroxalate CL as an energy source to excite photosensitizers has attracted tremendous attention in photodynamic therapy (PDT). In this work, peroxyoxalate CPPO and hypocrellin B (HB)-based nanoparticles (CBNPs) for ultrasound (US)-enhanced self-exciting PDT were designed and prepared. CBNPs showed an excellent therapeutic effect against cancer cells with the assistance of US. This US-enhanced-chemiluminescence system avoids the dependence on external light and provides an example for inspiring more effective and precise strategies for cancer treatment.
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