Analysis and Testing Center, College of Chemistry and Materials Science, Jiangsu Key Laboratory Biofunctional Materials, Nanjing Normal University, Nanjing 210046, China.
J Phys Chem B. 2012 Oct 25;116(42):12744-9. doi: 10.1021/jp305137j. Epub 2012 Oct 10.
Introduction of heavy atoms around photosensitizers (PSs) generally facilitates intersystem crossing (ISC) and improves their quantum yield of singlet oxygen ((1)O(2)) generation ability, which is a key species in photodynamic therapy (PDT). Here, we report Pt(IV)- and Au(III)-modified silica nanoparticles (SN) as the drug delivery system of a hypocrellin A (HA) to improve its photodynamic activity through external heavy atom effect. Comparative studies with Pt- and Au-modified and unmodified nanoparticles have demonstrated that the intraparticle external heavy atom effect on the encapsulated HA molecules significantly enhances their efficiency of (1)O(2) generation and, thereby, the in vitro photodynamic efficacy to cancer cells. The results well elucidated the potential of our PSs/heavy metal ions doped nanocarrier for improving the actual efficacy of PDT.
介绍光敏剂（PSs）周围的重原子通常可以促进系间窜越（ISC），并提高其单线态氧（(1)O(2)）生成能力的量子产率，这是光动力疗法（PDT）中的关键物质。在这里，我们报告了铂（IV）和金（III）修饰的二氧化硅纳米颗粒（SN）作为竹红菌素 A（HA）的药物递送系统，通过外部重原子效应来提高其光动力活性。与铂和金修饰和未修饰的纳米颗粒的比较研究表明，包裹在纳米颗粒内的HA 分子的内粒子外部重原子效应对其（1）O(2)生成效率有显著的增强作用，从而提高了体外对癌细胞的光动力疗效。结果很好地阐明了我们的 PSs/重金属离子掺杂纳米载体提高 PDT 实际疗效的潜力。
