School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210089, PR China.
Dalton Trans. 2019 Dec 7;48(45):16861-16868. doi: 10.1039/c9dt03706c. Epub 2019 Nov 11.
The efficiency of photosensitizers in tumor photodynamic therapy (PDT) often compromises their poor water solubility, low extinction coefficients, photobleaching, and dissatisfactory reactive oxygen species (ROS) generation efficiency. Herein, a nanoscale 2D metal-organic framework, Sm-HTCPP nanosheets, was first synthesized by Sm-driven coordination with a porphyrin derivative (tetrakis(4-carboxyphenyl)porphyrin (HTCPP)) for highly effective PDT of breast cancer. The prepared Sm-HTCPP possessed nanoplate morphology with ultrathin thickness at the sub-10 nm level and an ultrasmall plane size at the sub-100 nm level. Compared with free HTCPP, the prominent ROS generation capacity of the well-defined Sm-HTCPP nanosheets is mainly attributed to their improved physicochemical properties and the enhanced intersystem crossing caused by heavy Sm nodes. The significantly improved PDT efficacy of the Sm-HTCPP nanosheets was further investigated in vitro and in vivo based on the MCF-7 breast cancer model. It is envisaged that the Sm-HTCPP nanosheets will offer a new avenue for the development of a new class of potential PDT agents.
在肿瘤光动力疗法（PDT）中，光敏剂的效率往往受到其较差的水溶性、低消光系数、光漂白和不理想的活性氧（ROS）生成效率的影响。在此，首次通过 Sm 与卟啉衍生物（四（4-羧基苯基）卟啉（HTCPP））的配位合成了一种纳米级二维金属-有机骨架 Sm-HTCPP 纳米片，用于高效治疗乳腺癌的 PDT。所制备的 Sm-HTCPP 具有亚 10nm 级别的超薄厚度和亚 100nm 级别的超小平面尺寸的纳米片形态。与游离的 HTPCP 相比，明确的 Sm-HTCPP 纳米片具有突出的 ROS 生成能力，这主要归因于其改善的物理化学性质和重 Sm 节点引起的增强的系间窜越。进一步基于 MCF-7 乳腺癌模型在体外和体内研究了 Sm-HTCPP 纳米片的显著提高的 PDT 功效。预计 Sm-HTCPP 纳米片将为开发一类新的潜在 PDT 剂提供新途径。
