**甲虫烯 A 和 Epicoane A：一种** 产生的两种碳骨架
Beetleane A and Epicoane A: Two Carbon Skeletons Produced by .
机构信息
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom.
出版信息
Org Lett. 2021 May 7;23(9):3274-3277. doi: 10.1021/acs.orglett.1c00731. Epub 2021 Apr 21.
Two novel natural products, beetleane A () and epicoane A (), were obtained from the metabolites of an endophytic . Compound has a unique beetlelike structure that is constructed by the fusion and further fold of an unusual [5.5.5.6]trioxafenestrane with a cycloheptane ring. Compound possesses a compact cagelike structure with a unique 6/5/5/5/6/6/5 heptacyclic ring system. Both and showed strong antiliver fibrosis activity in vitro.
从一株内生真菌的代谢产物中分离得到两个新的天然产物，分别为甲虫烷 A（）和表考烷 A（）。化合物具有独特的甲虫样结构，是由一个不寻常的[5.5.5.6]三氧杂菲并烷与环己烷环融合和进一步折叠而成。化合物具有一个紧凑的笼状结构，具有独特的 6/5/5/5/6/6/5 七元环体系。和均显示出较强的体外抗肝纤维化活性。
Zotero 插件