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天然植物产物对抗阿尔茨海默病的作用。

Role of Natural Plant Products Against Alzheimer's Disease.

机构信息

Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India.

出版信息

CNS Neurol Disord Drug Targets. 2021;20(10):904-941. doi: 10.2174/1871527320666210420135437.

Abstract

Alzheimer's Disease (AD) is one of the major neurodegenerative disorders. Deposition of amyloid fibrils and tau protein is associated with various pathological symptoms. Currently, limited medication is available for AD treatment. Most of the drugs are basically cholinesterase inhibitors and associated with various side effects. Natural plant products have shown potential as a therapeutic agent for the treatment of AD symptoms. A variety of secondary metabolites such as flavonoids, tannins, terpenoids, alkaloids, and phenols are used to reduce the progression of the disease. Plant products have fewer or no side effects and are easily available. The present review gives a detailed account of the potential of natural plant products against AD symptoms.

摘要

阿尔茨海默病(AD)是主要的神经退行性疾病之一。淀粉样纤维和tau 蛋白的沉积与各种病理症状有关。目前,针对 AD 的治疗药物有限。大多数药物基本上都是胆碱酯酶抑制剂,并且伴随着各种副作用。天然植物产品已显示出作为治疗 AD 症状的治疗剂的潜力。各种次生代谢产物,如类黄酮、单宁、萜类、生物碱和酚类,被用于减缓疾病的进展。植物产品的副作用较少或没有,并且易于获得。本综述详细介绍了天然植物产品对抗 AD 症状的潜力。

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