Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Department of Thermal Technology and Food Process Engineering, University of Life Sciences in Lublin, Głęboka 31, 20-612 Lublin, Poland.
Int J Mol Sci. 2022 Jan 21;23(3):1212. doi: 10.3390/ijms23031212.
Neurodegenerative disorders such as Alzheimer's disease (AD) are distinguished by the irreversible degeneration of central nervous system function and structure. AD is characterized by several different neuropathologies-among others, it interferes with neuropsychiatrical controls and cognitive functions. This disease is the number one neurodegenerative disorder; however, its treatment options are few and, unfortunately, ineffective. In the new strategies devised for AD prevention and treatment, the application of plant-based natural products is especially popular due to lesser side effects associated with their taking. Moreover, their neuroprotective activities target different pathological mechanisms. The current review presents the anti-AD properties of several natural plant substances. The paper throws light on products under in vitro and in vivo trials and compiles information on their mechanism of actions. Knowledge of the properties of such plant compounds and their combinations will surely lead to discovering new potent medicines for the treatment of AD with lesser side effects than the currently available pharmacological proceedings.
神经退行性疾病，如阿尔茨海默病（AD），其特征是中枢神经系统功能和结构的不可逆转退化。AD 的特点是存在多种不同的神经病理学，其中包括干扰神经精神控制和认知功能。这种疾病是头号神经退行性疾病，但治疗选择很少，而且不幸的是，这些选择都无效。在制定 AD 的预防和治疗的新策略中，由于与使用相关的副作用较小，植物源性天然产物的应用特别受欢迎。此外，它们的神经保护活性针对不同的病理机制。目前的综述介绍了几种天然植物物质的抗 AD 特性。本文介绍了在体外和体内试验下的产品，并汇编了关于其作用机制的信息。对这些植物化合物及其组合的特性的了解，必将导致发现治疗 AD 的新的有效药物，其副作用比目前可用的药物要小。
