Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Department of Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Curr Opin Oncol. 2021 Jul 1;33(4):301-308. doi: 10.1097/CCO.0000000000000746.
The Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) is a bottom-up clinical network established in 2013 with the goal of improving the care and outcomes of patients with retroperitoneal sarcoma (RPS). Here, we review the knowledge produced by this collaborative effort and examine the future potential of this group.
TARPSWG has produced retrospective studies focused on patients with primary and recurrent RPS allowing a better understanding of patient prognosis, treatment outcomes and tumor biology. The group has played a pivotal role in a phase III randomized STudy of preoperative RAdiotherapy plus Surgery versus surgery alone for patients with Retroperitoneal Sarcoma (STRASS) trial, favoring patient recruitment and trial completion. A prospective registry for patients with primary RPS populated by TARPSWG members is ongoing. TARPSWG has created consensus papers with recommendations regarding the management of patients with primary, recurrent and metastatic RPS that collated the views of representatives of sarcoma centers from Europe, North America, Asia and Australia.
Since its inception, TARPSWG has become a leading network in the field of RPS. It has made a major contribution to the world of RPS research and cares allowing to overcome the limitations related to the rarity of the disease through collaboration.
大西洋-澳大拉西亚腹膜后肉瘤工作组（TARPSWG）是一个自下而上的临床网络，成立于 2013 年，旨在改善腹膜后肉瘤（RPS）患者的治疗效果和预后。在此，我们回顾了该协作组的研究成果，并探讨了该组织的未来潜力。
TARPSWG 进行了多项关于原发性和复发性 RPS 患者的回顾性研究，有助于更好地了解患者的预后、治疗效果和肿瘤生物学。该组织在一项 III 期随机试验（术前放疗加手术与单纯手术治疗腹膜后肉瘤的研究，STRASS）中发挥了关键作用，推动了患者招募和试验完成。一个由 TARPSWG 成员组成的原发性 RPS 前瞻性登记正在进行中。TARPSWG 还制定了关于原发性、复发性和转移性 RPS 患者管理的共识文件，这些文件汇总了来自欧洲、北美、亚洲和澳大利亚肉瘤中心代表的意见。
自成立以来，TARPSWG 已成为 RPS 领域的主要网络。它为 RPS 的研究和治疗领域做出了重大贡献，通过合作克服了该疾病罕见带来的限制。
