Schmitz Erika, Nessim Carolyn
Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Department of General Surgery, Division of Surgical Oncology, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Cancers (Basel). 2022 Mar 2;14(5):1293. doi: 10.3390/cancers14051293.
Soft-tissue sarcomas are biologically heterogenous tumors arising from connective tissues with over 100 subtypes. Although sarcomas account for <1% of all adult malignancies, retroperitoneal sarcomas are a distinct subgroup accounting for <10% of all sarcomatous tumors. There have been considerable advancements in the understanding and treatment of retroperitoneal sarcoma in the last decade, with standard treatment consisting of upfront primary surgical resection. The evidence surrounding the addition of radiation therapy remains controversial. There remains no standard with regards to systemic therapy, including immunotherapy. Adjunctive therapy remains largely dictated by expert consensus and preferences at individual centers or participation in clinical trials. In this 2021 review, we detail the anatomical boundaries of the retroperitoneum, clinical characteristics, contemporary standard of care and well as recent advancements in retroperitoneal sarcoma care. Ongoing international collaborations are encouraged to advance our understanding of this complex disease.
软组织肉瘤是起源于结缔组织的生物学异质性肿瘤，有100多种亚型。虽然肉瘤在所有成人恶性肿瘤中占比不到1%，但腹膜后肉瘤是一个独特的亚组，占所有肉瘤性肿瘤的不到10%。在过去十年中，腹膜后肉瘤的认识和治疗有了相当大的进展，标准治疗包括 upfront 原发性手术切除。关于放疗的添加的证据仍然存在争议。关于包括免疫疗法在内的全身治疗，目前尚无标准。辅助治疗在很大程度上仍取决于各中心的专家共识和偏好或参与临床试验。在这篇2021年的综述中，我们详细阐述了腹膜后的解剖边界、临床特征、当代护理标准以及腹膜后肉瘤护理的最新进展。鼓励正在进行的国际合作，以增进我们对这种复杂疾病的了解。
