Serova L D, Petrova M A
Ter Arkh. 1988;60(3):70-3.
A total of 235 patients with bronchial asthma and preasthma and their 85 relatives of the 1st degree of kinship were investigated. A detailed clinicofunctional and immunological investigation including a study of histocompatibility antigens, revealed the relationships between bronchial asthma development and antigens A2, B13, B21, B35 carriage. The authors presented a complex of methods (provocative acetylcholine tests, anaprilin test, determination of HLA antigens) permitting the prediction of this disease in patients with an aggravated hereditary and allergological history at the preclinical stage.
对235例支气管哮喘和哮喘前期患者及其85名一级亲属进行了调查。详细的临床功能和免疫学调查，包括组织相容性抗原研究，揭示了支气管哮喘的发生与携带A2、B13、B21、B35抗原之间的关系。作者提出了一套方法（乙酰胆碱激发试验、心得安试验、HLA抗原测定），可在临床前期对有严重遗传和变态反应病史的患者进行该病的预测。
