Department of Neurology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
Department of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022 Mar;166(1):57-62. doi: 10.5507/bp.2020.034. Epub 2020 Dec 7.
In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease.
The subthalamic nucleus was divided into two (dorsolateral/ventromedial) and three (dorsolateral, medial, ventromedial) parts. 37 deep brain stimulation electrodes were divided according to their active contact location. Correlation between change in non-motor symptoms before and one and four months after deep brain stimulation electrode implantation and the location of active contact was made.
In dividing the subthalamic nucleus into three parts, no electrode active contact was placed ventromedially, 28 active contacts were located in the medial part and 9 contacts were placed dorsolaterally. After one and four months, no significant difference was found between medial and dorsolateral positions. In the division of the subthalamic nucleus into two parts, 13 contacts were located in the ventromedial part and 24 contacts were placed in the dorsolateral part. After one month, significantly greater improvement in the Non-motor Symptoms Scale for Parkinson's disease (P=0.045) was found on dorsolateral left-sided stimulation, but no significant differences between the ventromedial and dorsolateral positions were found on the right side.
This study demonstrated the relationship between improvement of non-motor symptoms and the side (hemisphere, left/right) of the deep brain stimulation electrode active contact, rather than its precise location within specific parts of the subthalamic nucleus in patients treated for advanced Parkinson's disease.
本研究评估了深部脑刺激电极的活性接触位于不同亚核部位对改善帕金森病患者非运动症状的影响。
将亚核分为两部分（背外侧/腹内侧）和三部分（背外侧、内侧、腹内侧）。根据活性接触位置将 37 个深部脑刺激电极分为 37 个。比较深部脑刺激电极植入前后及植入后 1 个月和 4 个月非运动症状变化与活性接触位置的相关性。
将亚核分为三部分时，无电极活性接触位于腹内侧，28 个活性接触位于内侧部分，9 个位于背外侧。植入后 1 个月和 4 个月，内侧和背外侧位置之间无显著差异。将亚核分为两部分时，13 个接触位于腹内侧部分，24 个接触位于背外侧部分。植入后 1 个月，左侧背外侧刺激时帕金森病非运动症状量表（Non-motor Symptoms Scale for Parkinson's disease，NMSS）显著改善（P=0.045），但右侧腹内侧和背外侧位置之间无显著差异。
本研究表明，改善非运动症状与深部脑刺激电极活性接触的侧别（半球，左/右）相关，而不是与亚核特定部位的精确位置相关，对晚期帕金森病患者进行治疗。
