Thizy Delphine, Pare Toe Lea, Mbogo Charles, Matoke-Muhia Damaris, Alibu Vincent Pius, Barnhill-Dilling S Kathleen, Chantler Tracey, Chongwe Gershom, Delborne Jason, Kapiriri Lydia, Nassonko Kavuma Esther, Koloi-Keaikitse Sethlomo, Kormos Ana, Littler Katherine, Lwetoijera Dickson, Vargas de Moraes Roberta, Mumba Noni, Mutengu Lilian, Mwichuli Sylvia, Nabukenya Silvia Elizabeth, Nakigudde Janet, Ndebele Paul, Ngara Carolyne, Ochomo Eric, Odiwuor Ondiek Simon, Rivera Stephany, Roberts Aaron J, Robinson Benjamin, Sambakunsi Rodrick, Saxena Abha, Sykes Naima, Tarimo Brian B, Tiffin Nicki, Tountas Karen H
Imperial College London, London, UK.
Institut de Recherche en Science de la Santé, Ouagadougou, Burkina Faso.
Gates Open Res. 2021 Mar 24;5:19. doi: 10.12688/gatesopenres.13221.2. eCollection 2021.
Gene drive research is progressing towards future field evaluation of modified mosquitoes for malaria control in sub-Saharan Africa. While many literature sources and guidance point to the inadequacy of individual informed consent for any genetically modified mosquito release, including gene drive ones, (outside of epidemiological studies that might require blood samples) and at the need for a community-level decision, researchers often find themselves with no specific guidance on how that decision should be made, expressed and by whom. Target Malaria, the Kenya Medical Research Institute and the Pan African Mosquito Control Association co-organised a workshop with researchers and practitioners on this topic to question the model proposed by Target Malaria in its research so far that involved the release of genetically modified sterile male mosquitoes and how this could be adapted to future studies involving gene drive mosquito releases for them to offer reflections about potential best practices. This paper shares the outcomes of that workshop and highlights the remaining topics for discussion before a comprehensive model can be designed.
基因驱动研究正在朝着对经基因改造的蚊子进行实地评估的方向发展，以便在撒哈拉以南非洲地区控制疟疾。虽然许多文献资料和指南指出，对于任何转基因蚊子的释放，包括基因驱动蚊子（在可能需要采集血样的流行病学研究之外），个人知情同意是不够的，并且需要社区层面做出决策，但研究人员常常发现自己对于如何做出该决策、如何表达该决策以及由谁来做出该决策没有具体的指导。目标疟疾组织、肯尼亚医学研究所和泛非蚊虫控制协会就这一主题与研究人员和从业者共同举办了一次研讨会，以质疑目标疟疾组织在其迄今为止涉及释放转基因不育雄蚊的研究中所提出的模式，以及如何将该模式应用于未来涉及释放基因驱动蚊子的研究，以便他们能够对潜在的最佳实践进行思考。本文分享了该研讨会的成果，并强调了在设计出全面模式之前仍需讨论的主题。
