非甾体抗炎药和加巴喷丁类药物治疗慢性腰痛：随机对照试验的贝叶斯网状荟萃分析。
Non-steroidal anti-inflammatory drugs and gabapentinoids for chronic lumbar pain: a Bayesian network meta-analysis of randomized controlled trials.
机构信息
Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074 Aachen, Germany.
Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Salerno, Italy.
出版信息
Br Med Bull. 2021 Jun 10;138(1):85-95. doi: 10.1093/bmb/ldab003.
INTRODUCTION
Several pharmacological therapies have been proposed for the management of chronic low back pain (LBP), but no consensus has been reached yet.
SOURCE OF DATA
Recent published literatures identified accessing PubMed, Google scholar, Embase and Scopus.
AREAS OF AGREEMENT
Exploring effective conservative alternatives to the surgical intervention is of especial interest.
AREAS OF CONTROVERSY
The efficacy and safety of non-steroidal anti-inflammatory drugs and gabapentinoids for chronic LBP are debated. Several clinical studies showed controversial results, and the most effective and safe class of drugs has not yet been clarified.
GROWING POINTS
The effects of selective and non-selective NSAIDs and gabapentinoids in chronic LBP are probably over-estimated.
AREAS TIMELY FOR DEVELOPING RESEARCH
The effect of behavioural changes, including exercise, should be explored, alone or in combination with drugs.
简介
有几种药理学疗法已被提议用于治疗慢性下背痛（LBP），但尚未达成共识。
资料来源
最近发表的文献可通过访问 PubMed、Google Scholar、Embase 和 Scopus 获取。
共识领域
探索手术干预的有效保守替代方法特别令人关注。
争议领域
非甾体抗炎药和加巴喷丁类药物治疗慢性 LBP 的疗效和安全性存在争议。几项临床研究显示出有争议的结果，尚未明确最有效和安全的药物类别。
新的关注点
选择性和非选择性 NSAIDs 和加巴喷丁类药物在慢性 LBP 中的作用可能被高估了。
需要及时开展研究的领域
应单独或与药物联合探索行为改变（包括运动）的效果。
Zotero 插件