Department of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 108-8461, Japan.
Neurol Sci. 2021 Dec;42(12):5327-5334. doi: 10.1007/s10072-021-05238-7. Epub 2021 Apr 22.
Some patients with Parkinson's disease (PD) present with pareidolia, an illusion of a meaningless stimulus as a familiar object known to the observer. Since the striatum is associated with processing of visual information, we investigated correlations of pareidolia with motor symptoms and striatal dopaminergic function.
A noise pareidolia test, assessment of motor symptoms using MDS-UPDRS and I-Ioflupane SPECT were performed in 58 drug-naïve PD patients. A number of images in which a participant noticed an illusory face (number of illusory responses) were compared with motor assessment scores and uptake of I-ioflupane in the striatum.
Of the 58 participants, 22 had at least one illusory response. Mean scores for MDS-UPDRS part III (p<0.05), rigidity (p<0.05), and rigidity on the left side of the body (p<0.01) in patients with pareidolia were significantly higher than those in patients without pareidolia. Uptake of I-ioflupane in the right caudate nucleus (p<0.05), anterior putamen (p<0.01), and posterior putamen (p<0.01) in patients with pareidolia was significantly lower than in patients without pareidolia. In the 22 patients with pareidolia, the number of illusory responses was significantly correlated with total scores for MDS-UPDRS part III (r=0.443, p<0.05) and subscores for bradykinesia (r=0.440, p<0.05) and bradykinesia on the left side of the body (r=0.564, p<0.01). The prevalence of pareidolia in left-dominant parkinsonism (16/30 patients) was higher than that in right-dominant parkinsonism (6/28 patients) (p<0.05 by chi-square test).
Pareidolia in PD patients is associated with dysfunction in the right striatum.
一些帕金森病（PD）患者会出现错觉，即观察者将无意义的刺激视为熟悉的物体。由于纹状体与视觉信息的处理有关，我们研究了错觉与运动症状和纹状体多巴胺能功能之间的相关性。
对 58 名未经药物治疗的 PD 患者进行噪声错觉测试、MDS-UPDRS 运动评估和 I-ioflupane SPECT。比较参与者注意到幻觉面孔的次数（幻觉反应次数）与运动评估评分和纹状体 I-ioflupane 摄取之间的关系。
58 名参与者中，有 22 名至少有一次幻觉反应。有错觉的患者 MDS-UPDRS 第三部分评分（p<0.05）、僵硬评分（p<0.05）和左侧身体僵硬评分（p<0.01）明显高于无错觉的患者。有错觉的患者右侧尾状核（p<0.05）、前壳核（p<0.01）和后壳核（p<0.01）的 I-ioflupane 摄取明显低于无错觉的患者。在 22 名有错觉的患者中，幻觉反应次数与 MDS-UPDRS 第三部分总分（r=0.443，p<0.05）和左半身运动迟缓（r=0.440，p<0.05）和左半身运动迟缓（r=0.564，p<0.01）评分显著相关。左优势型帕金森病（30 例中有 16 例）错觉的发生率高于右优势型帕金森病（28 例中有 6 例）（卡方检验，p<0.05）。
PD 患者的错觉与右侧纹状体功能障碍有关。
