Pikstra Angelina R A, van der Hoorn Anouk, Leenders Klaus L, de Jong Bauke M
Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands.
Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands; Department of Radiology, University Medical Centre Groningen, University of Groningen, The Netherlands.
Neuroimage Clin. 2016 Jan 12;11:68-72. doi: 10.1016/j.nicl.2016.01.010. eCollection 2016.
In this retrospective study concerning patients with Parkinson's disease (PD) scanned with 18-F-Dopa PET (N = 129), we looked for an association between reduced 18-F-Dopa uptake and the key PD symptoms tremor and hypokinesia-rigidity. We hypothesized to find a stronger correlation between dopaminergic depletion in the striatum and hypokinesia-rigidity compared to tremor.
The onset side of symptoms (documented for 102 patients) as well as the first registered UPDRS (available for 79 patients) was used to correlate with F-Dopa uptake values in the caudate nucleus and putamen in this large retrospective sample.
Reduced F-Dopa uptake was contralateral to hypokinesia-rigidity symptoms and correlated with its severity (quantified by UPDRS). For tremor severity, no correlation was seen with F-Dopa reduction. Furthermore, freezing of gait correlated with reduced F-Dopa uptake in the putamen of the right hemisphere.
Our results, obtained in a large patient group, provides support for the concept that tremor in PD is not only based on a dopamine related pathway but may rely on a different pathway.
在这项针对129例接受18-F-多巴PET扫描的帕金森病（PD）患者的回顾性研究中，我们探寻18-F-多巴摄取减少与PD关键症状震颤及运动迟缓-强直之间的关联。我们假设相较于震颤，纹状体中多巴胺能耗竭与运动迟缓-强直之间的相关性更强。
在这个大型回顾性样本中，使用症状的起始侧（记录了102例患者）以及首次记录的统一帕金森病评定量表（UPDRS，79例患者可用）与尾状核和壳核中的F-多巴摄取值进行关联分析。
F-多巴摄取减少与运动迟缓-强直症状对侧相关，且与其严重程度（通过UPDRS量化）相关。对于震颤严重程度，未发现与F-多巴减少相关。此外，步态冻结与右半球壳核中F-多巴摄取减少相关。
我们在一个大型患者群体中获得的结果支持了这样一种观点，即PD中的震颤不仅基于多巴胺相关通路，可能还依赖于不同的通路。
