Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Department of NanoEngineering, University of California San Diego, Jacobs School of Engineering, La Jolla, CA, 92093, USA.
Macromol Biosci. 2021 Jul;21(7):e2000328. doi: 10.1002/mabi.202000328. Epub 2021 Apr 22.
Antibiotic-loaded poly(methyl methacrylate) (PMMA) cement is commonly used as a local delivery system to treat and prevent orthopedic infections associated with arthroplasties in load-bearing applications. However, these delivery systems are inefficient as release rate sharply declines to subinhibitory levels. Prior studies have shown that by adding in drug-filled cyclodextrin (CD) microparticles into PMMA cement, a more consistent release is observed, and antibiotic refilling through simulated implantation can be achieved. However, the mechanical strengths of PMMA is reduced. In order to decrease the mechanical loss, modified CD microparticles (PMMA-CD) are synthesized that contain covalently appended PMMA chains. The compressive strengths, handling characteristics, and refilling ability of PMMA cement with PMMA-CD are evaluated. Specifically, up to a 13.7% increase in compressive strength is observed when unmodified CD is substituted with PMMA-CD in PMMA samples with 10 wt% CD microparticles. Additionally, a 13.3% increase in working time, a 7.5% decrease in maximum polymerization temperature, and up to a 32.1% increase in amount of drug refilled are observed with the addition of 10 wt% CD PMMA-CD into PMMA in comparison to plain PMMA without CD microparticles.
载抗生素聚甲基丙烯酸甲酯（PMMA）骨水泥常被用作局部给药系统，以治疗和预防与承重应用中的关节置换相关的骨科感染。然而，这些给药系统效率低下，因为释放速率急剧下降至亚抑菌水平。先前的研究表明，通过向 PMMA 骨水泥中添加载药环糊精（CD）微球，可以观察到更一致的释放，并且可以通过模拟植入来实现抗生素再填充。然而，PMMA 的机械强度降低。为了降低机械损失，合成了修饰后的 CD 微球（PMMA-CD），其中含有共价连接的 PMMA 链。评估了含有 PMMA-CD 的 PMMA 骨水泥的抗压强度、操作特性和再填充能力。具体来说，当在含有 10wt%CD 微球的 PMMA 样品中用 PMMA-CD 替代未修饰的 CD 时，抗压强度增加了 13.7%。此外，与不含 CD 微球的普通 PMMA 相比，添加 10wt%CD PMMA-CD 可使工作时间延长 13.3%，最大聚合温度降低 7.5%，可再填充药物的量增加 32.1%。
