Department of Paediatric Dentistry, Pacific Dental College and Hospital, Udaipur, Rajasthan, India.
J Indian Soc Pedod Prev Dent. 2021 Jan-Mar;39(1):36-41. doi: 10.4103/jisppd.jisppd_527_20.
Propylthiouracil (PROP) (a medicated tool) and hormonal fingerprint (second to fourth digits [2D:4D]) ratio can be used for detection of caries which is most prevalent oral health disease.
This study aims to determine the role of genetic taste sensitivity and hormonal fingerprint (2D:4D ratio) on caries risk susceptibility.
The present study was an observational and cross-sectional study. It was conducted on 570 children aged 6-12 years. PROP sensitivity test was done by PROP impregnated filter paper strips and subjects were divided accordingly into supertasters, medium-tasters, and nontasters. 2D:4D ratio was obtained by measuring length ratio of index to ring finger using Vernier caliper. Dietary preferences of the subjects were recorded. The evaluation of decayed, missing, and filled teeth/deft indices was done.
Intergroup comparisons were performed using One-way ANOVA test, independent t-test and Chi-square test at 5% significance level.
Positive correlation between nontasters, low digit ratio, sweet likers, and high caries index was found with a high significant difference.
Genetic taste sensitivity and hormonal fingerprint (biological marker) can be used for detection of caries as the present research confirmed impact of hormones on taste perception.
丙硫氧嘧啶（PROP）（一种药物工具）和激素指纹（第二到第四指[2D:4D]）比值可用于检测最常见的口腔健康疾病龋齿。
本研究旨在确定遗传味觉敏感性和激素指纹（2D:4D 比值）对龋齿易感性的作用。
本研究为观察性和横断面研究。对 570 名 6-12 岁的儿童进行了研究。通过 PROP 浸渍滤纸条进行 PROP 敏感性测试，根据测试结果将受试者分为超级味觉者、中等味觉者和非味觉者。使用游标卡尺测量食指与无名指的长度比，得出 2D:4D 比值。记录受试者的饮食偏好。对龋齿、缺失和填充的牙齿/缺失牙指数（deft index）进行评估。
采用单因素方差分析、独立 t 检验和卡方检验在 5%的显著性水平上进行组间比较。
发现非味觉者、低指比值、甜食爱好者和高龋齿指数之间存在正相关，且差异具有统计学意义。
遗传味觉敏感性和激素指纹（生物标志物）可用于龋齿检测，因为本研究证实了激素对味觉感知的影响。
