Kulshrestha Anika, Shah Preetam, Jagtap Chetana, Patil Smita, Kunte Sanket, Chaudhary Shweta
Department of Pediatric and Preventive Dentistry, Dental College and Hospital, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Int J Clin Pediatr Dent. 2024 Jun;17(6):690-694. doi: 10.5005/jp-journals-10005-2893.
Genetic predilection toward sweeter cariogenic foods mediated by the gene, tested by phenylthiourea [phenylthiocarbamide (PTC)] compounds. Some individuals find it extremely bitter whereas some find it completely tasteless, being classified as a taster and a nontaster respectively. A majority of nontasters prefer foods with sweeter and stronger flavors, thus making them more susceptible to dental caries. Genetic taste perception is greatly influenced by prenatal androgen exposure represented by hormonal fingerprint, that is, ratio of second to fourth digit lengths (2D:4D ratio), thus making it a precise biomarker to quantify an individual's genetic taste perception and in turn their caries susceptibility.
To find a correlation of genetic taste perception with the hormonal fingerprint and dental caries prevalence in children.
A total of 96 children were selected at random for the study and divided into two groups based on their gender. A genetic taste perception test was carried out using PTC strips, and they were classified as tasters and nontasters. Then, the hormonal fingerprint was recorded by calculating the ratio of the index finger and ring finger. Following this, decayed, missing, and filled teeth index (DMFT) was recorded.
A strong positive correlation was observed among nontasters, with a preference for sweeter foods associated with a high caries index. Conversely, no relationship was found between genetic taste perception and the hormonal fingerprint.
The present study positively demonstrates an association of genetic taste perception and dental caries due to an increased preference for sweeter foods among nontasters. Although no correlation was found between the genetic taste perception, the hormonal fingerprint, and the dental caries status of an individual.
Kulshrestha A, Shah P, Jagtap C, Assessment of Correlation between Genetic Taste Perception Hormonal Fingerprint and Dental Caries Incidence in Schoolgoing Children: An Study. Int J Clin Pediatr Dent 2024;17(6):690-694.
由基因介导的对更甜的致龋食物的遗传倾向，通过苯硫脲[苯硫代碳酰胺（PTC）]化合物进行测试。一些人觉得它极其苦涩，而另一些人则觉得它完全无味，分别被归类为尝味者和非尝味者。大多数非尝味者更喜欢味道更甜、更浓郁的食物，因此他们更容易患龋齿。遗传味觉感知受激素指纹所代表的产前雄激素暴露的极大影响，即食指与无名指长度之比（2D:4D比值），因此它成为量化个体遗传味觉感知进而其龋齿易感性的精确生物标志物。
探究儿童遗传味觉感知与激素指纹及龋齿患病率之间的相关性。
随机选取96名儿童参与本研究，并根据性别分为两组。使用PTC试纸进行遗传味觉感知测试，并将他们分为尝味者和非尝味者。然后，通过计算食指与无名指的比例来记录激素指纹。在此之后，记录龋失补牙指数（DMFT）。
在非尝味者中观察到强烈的正相关，对更甜食物的偏好与高龋齿指数相关。相反，未发现遗传味觉感知与激素指纹之间存在关联。
本研究有力地证明了遗传味觉感知与龋齿之间的关联，原因是非尝味者对更甜食物的偏好增加。尽管未发现个体的遗传味觉感知、激素指纹与龋齿状况之间存在相关性。
库尔什雷斯塔A，沙阿P，贾格塔普C，学龄儿童遗传味觉感知、激素指纹与龋齿发病率相关性的评估：一项研究。《国际临床儿科牙科学杂志》2024；17(6):690 - 694。
