长期血清特异性抗基孔肯雅 IgM 抗体的持久性 - 巴西患者的病例系列。
Long-Term Persistence of Serum-Specific Anti-Chikungunya IgM Antibody - A Case Series of Brazilian Patients.
机构信息
Universidade Federal de Pernambuco, Hospital das Clínicas, Recife, PE, Brasil.
Universidade Federal de Pernambuco, Departamento de Virologia, Laboratório de Imunopatologia Keizo Asami, Recife, PE, Brasil.
出版信息
Rev Soc Bras Med Trop. 2021 Apr 12;54:e0855. doi: 10.1590/0037-8682-0855-2020. eCollection 2021.
Abstract
The persistence of serum-specific anti-chikungunya IgM antibodies (CHIKV-IgM) can vary after chikungunya fever (CHIK) infection. However, the factors related to its production are not yet known. We described a case series drawn up from data collected from 57 patients between 12 and 36 months after the acute phase of CHIK infection in Northeastern Brazil. CHIKV-IgM was detectable in 7/57 (12.3%) patients after 28.3 months of infection. No frequency differences in chronic musculoskeletal manifestations and underlying conditions were detected between patients with or without CHIKV-IgM. CHIKV-IgM was detected for up to 35 months in Brazilian patients after CHIK infection.
摘要
在感染基孔肯雅热（CHIK）后，血清特异性抗基孔肯雅病毒 IgM 抗体（CHIKV-IgM）的持续存在情况可能有所不同。然而，其产生的相关因素尚不清楚。我们描述了一组病例系列，这些病例是从巴西东北部 CHIK 感染急性期后 12 至 36 个月期间收集的 57 名患者的数据中得出的。在感染 28.3 个月后，7/57（12.3%）名患者可检测到 CHIKV-IgM。在有无 CHIKV-IgM 的患者中，慢性肌肉骨骼表现和基础疾病的发生频率没有差异。在巴西患者中，CHIK 感染后 CHIKV-IgM 可检测长达 35 个月。
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