Parker Daniel M, Haileselassie Werissaw, Hailemariam Temesgen Sisay, Workenh Arsema, Workineh Salle, Wang Xiaoming, Lee Ming-Chieh, Yan Guiyun
Department of Population Health and Disease Prevention; University of California, Irvine; U.S.A.
Department of Epidemiology & Biostatistics; University of California, Irvine; U.S.A.
medRxiv. 2024 Sep 26:2024.09.19.24313917. doi: 10.1101/2024.09.19.24313917.
-borne diseases infect millions of people each year. In the last decade several arbovirus outbreaks have been reported in Ethiopia. Arbovirus diagnosis and surveillance is lacking and the true burden is unknown. In this study we conducted a seroprevalence survey using a commercially available test kit that that tests for immunological responses to IgM and IgG for dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses in Dire Dawa city, eastern Ethiopia. We found a high IgG seroprevalence for DENV (76%), CHIKV (44%), and ZIKV (38%), and <20% IgM seropositivity across all viruses. As a comparison, we conducted serosurveillance in Addis Ababa, the national capital with no reported history of arbovirus outbreaks. The highest seropositivity we found was to IgM for DENGV at approximately 3%. Our results suggest both past and recent widespread exposure to these arboviruses, underscoring the need for improved surveillance and public health interventions in Ethiopia.
虫媒传播疾病每年感染数百万人。在过去十年中，埃塞俄比亚报告了几起虫媒病毒疫情。虫媒病毒诊断和监测工作缺乏，实际负担尚不清楚。在本研究中，我们使用一种市售检测试剂盒进行了血清流行率调查，该试剂盒检测埃塞俄比亚东部德雷达瓦市登革热病毒（DENV）、寨卡病毒（ZIKV）和基孔肯雅病毒（CHIKV）的IgM和IgG免疫反应。我们发现DENV的IgG血清流行率很高（76%），CHIKV为（44%），ZIKV为（38%），所有病毒的IgM血清阳性率均<20%。作为对比，我们在没有虫媒病毒疫情报告历史的国家首都亚的斯亚贝巴进行了血清监测。我们发现的最高血清阳性率是DENGV的IgM，约为3%。我们的结果表明过去和近期这些虫媒病毒都有广泛传播，这凸显了埃塞俄比亚加强监测和公共卫生干预措施的必要性。
