患有基孔肯雅病毒感染并持续存在特异性 IgM 抗体的患者发生破坏性关节炎。
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies.
机构信息
Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, F-33075 France.
出版信息
BMC Infect Dis. 2009 Dec 10;9:200. doi: 10.1186/1471-2334-9-200.
BACKGROUND
Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.
CASE PRESENTATION
We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.
CONCLUSIONS
Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.
背景
基孔肯雅热是一种新兴的虫媒病毒性疾病，其特征为发热性出疹、炎症性多关节炎或腱鞘炎，可持续数月至数年。迄今为止，慢性期的病理生理学仍知之甚少。
病例介绍
我们报告首例 CHIKV 感染后慢性相关风湿病病例，该患者在感染后 24 个月出现进行性侵蚀性关节炎，表现为炎症介质表达和特异性 IgM 抗体持续存在。
结论
了解基孔肯雅病毒的具体特征以及病毒与宿主相互作用的方式对于基孔肯雅病的预防、治疗或治愈至关重要。
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