Sharma O P, Dawra R K, Krishna L, Makkar H P
Indian Veterinary Research Institute, Regional Station, Kangra Valley, India.
Vet Hum Toxicol. 1988 Jun;30(3):214-8.
Oral administration of lantana leaves (6 g/kg body weight) and isolated toxins (125 mg/kg body weight) to rabbits caused ictericity, anorexia and decrease in fecal output. There was increased size of the kidneys, and the livers were ochre-colored and fragile but there was no hepatomegaly. Histopathologically, lantana-intoxicated rabbits had swellings of hepatic cells, portal fibrosis, dilatation of bile canaliculi and biliary hyperplasia. Kidneys had proliferation of mesenchymal cells in glomerular tufts, degeneration of tubules, swelling of tubular epithelial cells and pyknosis of nuclei. The intoxicated animals had elevated levels of conjugated and unconjugated bilirubin in plasma, the major increase being in the conjugated form (suggestive of obstructive jaundice). There were marginal changes in the activities of acid phosphatase and glutamate oxaloacetate transaminase in the plasma.
给兔子口服马缨丹叶（6克/千克体重）和分离出的毒素（125毫克/千克体重）会导致黄疸、厌食和粪便排出量减少。肾脏体积增大，肝脏呈赭色且脆弱，但无肝肿大。组织病理学检查显示，马缨丹中毒的兔子肝细胞肿胀、门静脉纤维化、胆小管扩张和胆管增生。肾脏肾小球簇间质细胞增生、肾小管变性、肾小管上皮细胞肿胀和细胞核固缩。中毒动物血浆中结合胆红素和非结合胆红素水平升高，主要是结合形式升高（提示梗阻性黄疸）。血浆中酸性磷酸酶和谷氨酸草酰乙酸转氨酶的活性有轻微变化。
