Sharma O P, Makkar H P, Dawra R K, Negi S S
Clin Toxicol. 1981 Sep;18(9):1077-94. doi: 10.3109/15563658108990337.
Lantana poisoning has been taking a heavy toll of livestock year after year. All aspects of the problem are reviewed. Lantana poisoning in cattle, sheep, buffalo, and guinea pigs caused obstructive jaundice, photosensitization, and rise in serum glutamicoxaloaetic transaminase activity. The symptoms could be reproduced in sheep by administration of purified Lantadene A. Liver and kidneys are the most affected organs during lantana poisoning. Intoxication of guinea pigs with Lantana camara leads to marked alterations in major tissue constituents in liver an kidneys. Hepatic and renal xanthine oxidase activity is also elevated during lantana poisoning. No antidote is available against the toxic section of Lantana camara. Symptomatic treatments have been proposed with limited success. Knowledge of the biochemical mechanism of lantana intoxication at the cellular, subcellular, and molecular levels is essential in order to evolve a successful antidote and more rational therapy during lantana intoxication.
马缨丹中毒年复一年地给牲畜造成了巨大损失。对该问题的各个方面进行了综述。牛、羊、水牛和豚鼠的马缨丹中毒会导致阻塞性黄疸、光敏反应以及血清谷氨酸草酰乙酸转氨酶活性升高。通过给绵羊施用纯化的马缨丹烯A可重现这些症状。在马缨丹中毒期间，肝脏和肾脏是受影响最严重的器官。用马缨丹使豚鼠中毒会导致肝脏和肾脏的主要组织成分发生明显变化。在马缨丹中毒期间，肝脏和肾脏的黄嘌呤氧化酶活性也会升高。目前尚无针对马缨丹毒性作用的解毒剂。已提出对症治疗，但效果有限。为了在马缨丹中毒期间研发出成功的解毒剂和更合理的治疗方法，了解马缨丹中毒在细胞、亚细胞和分子水平的生化机制至关重要。
