Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos, Mexico.
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos, Mexico.
Curr Opin Virol. 2021 Jun;48:42-48. doi: 10.1016/j.coviro.2021.03.011. Epub 2021 Apr 19.
Rotaviruses are important agents of severe gastroenteritis in young children, and show a very selective cell and tissue tropism, as well as significant age and host restriction. In the last few years, these properties have been associated with the initial interaction of the virus with histo-blood group antigens on the cell surface, although post-attachment interactions have also been found to define the susceptibility to infection of human enteroids. These initial interactions seem also to determine the virus entry pathway, as well as the induction of signaling cascades that influence the virus intracellular vesicular traffic and escape from endosomes. Here we review the current knowledge of the different stages of the virus entry journey.
轮状病毒是导致婴幼儿严重肠胃炎的重要病原体，具有非常特殊的细胞和组织嗜性，以及显著的年龄和宿主限制。在过去的几年中，这些特性与病毒与细胞表面的组织血型抗原的初始相互作用有关，尽管附着后的相互作用也被发现可以定义人类类器官对感染的易感性。这些初始相互作用似乎也决定了病毒进入的途径，以及诱导信号级联反应，从而影响病毒细胞内囊泡运输并从内体逃逸。在这里，我们回顾了病毒进入旅程的不同阶段的现有知识。
