Arias Carlos F, Silva-Ayala Daniela, López Susana
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Colonia Chamilpa, Cuernavaca, Morelos, México
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Colonia Chamilpa, Cuernavaca, Morelos, México.
J Virol. 2015 Jan 15;89(2):890-3. doi: 10.1128/JVI.01787-14. Epub 2014 Nov 5.
Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young children worldwide. These nonenveloped viruses enter cells using different types of endocytosis and, depending on the virus strain, travel to different endosomal compartments before exiting to the cytosolic space. In this Gem, we review the viral and cellular factors involved in the different stages of a productive virus cell entry and share with the readers the journey that we have taken into the cell to learn about virus entry.
轮状病毒是全球婴幼儿急性胃肠炎的主要病原体。这些无包膜病毒通过不同类型的内吞作用进入细胞,并根据病毒株的不同,在进入胞质空间之前前往不同的内体区室。在这篇文章中,我们回顾了病毒生产性进入细胞不同阶段所涉及的病毒和细胞因子,并与读者分享我们深入细胞了解病毒进入过程的历程。