Department of Physiology (UG & PG), 212035Serampore College, Hooghly, West Bengal, India.
Hum Exp Toxicol. 2021 Nov;40(11):1825-1851. doi: 10.1177/09603271211010895. Epub 2021 Apr 22.
Since prehistoric times has been used as traditional medicine for various diseases including diabetes, dyslipidemia, metabolic and digestive disorders. Although the rationality of efficacy as natural antioxidants with different bioactive compounds in against monosodium glutamate (MSG) induced hepato-cardiac damage remains to be disclosed. Six different solvent extracts of the leaves of were chosen to evaluate antioxidant and free radical (FR)-scavenging activity. Due to high antioxidant content and FR-scavenging property of ethanol extract of leaves (EECGL) and presence of different bioactive compounds in EECGL was further tested to evaluate hepato-protective and cardio-protective efficacy against MSG-induced anomalies. MSG-induced dyslipidemia, increased cell toxicity markers altered functional status and histopathological peculiarities of target organs were blunted by EECGL. Additionally, MSG incited increase level of interleukin (IL)-6, tumour necrosis factor (TNF)-α, IL-1β which activates nuclear factor kappa-B (NF-kB) guided inflammation via down regulation of IL-10; impaired redox-homeostasis subsequently promoted inflammation associated oxidative stress (OS) and increased vascular endothelial growth factor (VEGF) which provoked microvascular proliferation related cellular damage. On the contrary, increased lipid peroxidation and nitric oxide promotes reduced cell viability, deoxyribonucleic acid damage and apoptosis via activation of caspase 3. EECGL significantly reduced MSG-induced inflammation mediated OS and apoptosis via inhibition of pro-inflammatory factors and pro-apoptotic mediators to protect liver and heart. Therefore, it can be suggested that EECGL contributed competent scientific information to validate the demands for its use to treat MSG-induced hepato-cardiac OS mediated inflammation and apoptosis from natural origin.
自古以来， 一直被用作传统药物，用于治疗各种疾病，包括糖尿病、血脂异常、代谢和消化紊乱。尽管其作为天然抗氧化剂的功效的合理性，以及其不同生物活性化合物对单谷氨酸钠（MSG）诱导的肝-心脏损伤的作用，仍有待揭示。我们选择了 的叶子的六种不同溶剂提取物，以评估其抗氧化和自由基（FR）清除活性。由于 叶乙醇提取物（EECGL）具有高抗氧化含量和 FR 清除特性，以及其中存在不同的生物活性化合物，因此进一步测试了其对 MSG 诱导的异常的肝保护和心脏保护作用。EECGL 减轻了 MSG 诱导的血脂异常、增加的细胞毒性标志物、改变的功能状态以及目标器官的组织病理学特征。此外，MSG 引发白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α、IL-1β水平升高，通过下调 IL-10 激活核因子 kappa-B（NF-kB）引导炎症；随后破坏氧化还原稳态，促进与炎症相关的氧化应激（OS）和血管内皮生长因子（VEGF）增加，引发与微血管增殖相关的细胞损伤。相反，增加的脂质过氧化和一氧化氮通过激活 caspase 3 促进降低的细胞活力、脱氧核糖核酸损伤和细胞凋亡。EECGL 通过抑制促炎因子和促凋亡介质，显著减轻了 MSG 诱导的炎症介导的 OS 和细胞凋亡，从而保护了肝脏和心脏。因此，可以认为 EECGL 为其作为天然来源治疗 MSG 诱导的肝-心脏 OS 介导的炎症和凋亡的用途提供了有力的科学信息。
