Zhang Hua, Wang Bo, He Jie, Du Zhongju
Department of Anesthesiology and Pain Management, The Third People's Hospital of Hangzhou, Hangzhou, Zhejiang, China.
J Int Med Res. 2021 Apr;49(4):3000605211006647. doi: 10.1177/03000605211006647.
To evaluate the efficacy and safety of radiofrequency ablation for the treatment of knee osteoarthritis.
A literature review was conducted using the PubMed, Cochrane Review, Embase, and Google Scholar databases. Two reviewers independently assessed the eligibility of all retrieved studies. The research was reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure the reliability and verity of the results. The statistical analysis was performed using STATA version 13.0.
Nine randomized controlled trials were collected for the data extraction and meta-analysis. Significant differences in the pain score at 4, 12, and 24 weeks were found between patients treated with radiofrequency ablation and those treated with placebo. Furthermore, the use of radiofrequency ablation was associated with an improved outcome of the Western Ontario and McMaster Universities Arthritis Index at 4, 12, and 24 weeks. No serious adverse events were observed in any patients who underwent radiofrequency ablation.
Radiofrequency ablation is efficacious and safe for reducing pain and improving knee function in patients with knee osteoarthritis, without increasing the risk of adverse effects.
评估射频消融治疗膝关节骨关节炎的疗效和安全性。
使用PubMed、Cochrane系统评价、Embase和谷歌学术数据库进行文献综述。两名评价者独立评估所有检索到的研究的纳入资格。研究报告遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，以确保结果的可靠性和真实性。使用STATA 13.0进行统计分析。
收集了9项随机对照试验进行数据提取和Meta分析。发现接受射频消融治疗的患者与接受安慰剂治疗的患者在4周、12周和24周时的疼痛评分存在显著差异。此外，在4周、12周和24周时，使用射频消融与改善西安大略和麦克马斯特大学骨关节炎指数的结果相关。接受射频消融的患者均未观察到严重不良事件。
射频消融在减轻膝关节骨关节炎患者疼痛和改善膝关节功能方面是有效且安全的，不会增加不良反应风险。
