射频消融治疗膝骨关节炎：系统评价和荟萃分析。

Radiofrequency ablation therapy for knee osteoarthritis: a systematic review and meta-analysis.

机构信息

Department of Orthopaedic Surgery.

Department of Nursing. The first affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China.

出版信息

Cir Cir. 2024;92(4):456-468. doi: 10.24875/CIRU.23000395.

DOI:10.24875/CIRU.23000395

PMID:39079243

Abstract

OBJECTIVE

The objective of the study is to systematically analyze the safety and efficacy of radiofrequency ablation (RFA) therapy for the treatment of patients with knee osteoarthritis (KOA) and to assess the methodological quality of the published studies.

METHODS

By searching the PubMed, Embase, and CENTRAL databases, we retrieved and collected relevant randomized controlled trials (RCTs) published up to June 26, 2023.

RESULTS

We included 13 RCTs, involving a total of 865 patients. Compared with the control group, the RFA group had significantly reduced pain scores at 1-2 weeks, 4 weeks, 12 weeks, and 24 weeks post-treatment, with standardized mean differences of -1.24 (95% confidence interval [CI]: -1.99--0.49; p = 0.001; I = 91%), -0.76 (95% CI: -1.27--0.26; p = 0.003; I = 76%), -1.70 (95% CI: -2.56--0.83; p = 0.0001; I = 94%), and -2.26 (95% CI: -3.49--1.04; p = 0.0003; I = 95%).

CONCLUSIONS

RFA, as an adjunctive treatment modality, demonstrates potential in the treatment of patients with KOA. This method may become a primary treatment strategy for these patients.

摘要

目的

本研究旨在系统分析射频消融（RFA）治疗膝骨关节炎（KOA）患者的安全性和疗效，并评估已发表研究的方法学质量。

方法

通过检索 PubMed、Embase 和 CENTRAL 数据库，我们检索并收集了截至 2023 年 6 月 26 日发表的相关随机对照试验（RCT）。

结果

我们纳入了 13 项 RCT，共 865 名患者。与对照组相比，RFA 组在治疗后 1-2 周、4 周、12 周和 24 周时疼痛评分显著降低，标准化均数差值分别为-1.24（95%置信区间 [CI]：-1.99~~-0.49；p = 0.001；I² = 91%）、-0.76（95% CI：-1.27~~-0.26；p = 0.003；I² = 76%）、-1.70（95% CI：-2.56~~0.83；p = 0.0001；I² = 94%）和-2.26（95% CI：-3.49~~1.04；p = 0.0003；I² = 95%）。