From the Department of Radiology, University of Minnesota, Minneapolis, Minnesota
From the Department of Radiology, University of Minnesota, Minneapolis, Minnesota.
AJNR Am J Neuroradiol. 2021 Jun;42(6):1136-1143. doi: 10.3174/ajnr.A7143. Epub 2021 Apr 22.
Gadolinium complexes have paramagnetic properties; thus, we aimed to determine the susceptibility changes in the globus pallidus and dentate nucleus following administration of linear or macrocyclic gadolinium-based contrast agents in children.
Thirty-three patients with linear gadolinium-based contrast agent gadopentetate dimeglumine administration, 33 age- and sex-matched patients with macrocyclic gadolinium-based contrast agent gadobutrol administration, and 33 age- and sex-matched control subjects without gadolinium exposure were enrolled in this retrospective study. The signal intensity on SWI and T1WI was determined in the dentate nucleus, middle cerebellar peduncle, globus pallidus, and pulvinar of the thalamus in an ROI-based analysis to calculate dentate nucleus-to-middle cerebellar peduncle and globus pallidus-to-thalamus ratios. A repeated measures ANOVA was performed to compare SWI, SWI, and T1WI signal intensity ratios between gadolinium-based contrast agent groups and control subjects. Pearson correlation analysis was performed to determine any correlation between signal intensity ratios and variables.
Dentate nucleus-to-middle cerebellar peduncle and globus pallidus-to-thalamus ratios for both SWI and SWI were lower for the linear gadolinium-based contrast agent group compared with macrocyclic gadolinium-based contrast agent and control groups ( < .05). No significant difference of the SWI and SWI ratios were noted between the macrocyclic gadolinium-based contrast agent group and the control group ( > .05). Both dentate nucleus-to-middle cerebellar peduncle and globus pallidus-to-thalamus ratios on T1WI in the linear gadolinium-based contrast agent group were higher than in the control group and the macrocyclic gadolinium-based contrast agent group ( < .05). A negative correlation was identified between SWI and SWI ratios and the number of linear gadolinium-based contrast agent administrations (dentate nucleus-to-middle cerebellar peduncle ratio: SWI, = -0.43, = .005; SWI, = -0.38, = .011; globus pallidus-to-thalamus ratio: SWI, = -0.39, = .009; SWI, = -0.33, = .017).
SWI analysis of the pediatric brain demonstrated a statistically significant decrease in SWI and SWI values for the dentate nucleus and globus pallidus after administration of linear gadolinium-based contrast agents but not macrocyclic gadolinium-based contrast agents.
钆复合物具有顺磁性；因此，我们旨在确定在儿童中使用线性或大环类基于钆的造影剂后苍白球和齿状核的磁化率变化。
本回顾性研究纳入了 33 例接受线性基于钆造影剂钆喷替酸二甲葡胺注射的患者、33 例年龄和性别匹配的接受大环类基于钆造影剂钆布醇注射的患者和 33 例无钆暴露的年龄和性别匹配的对照组。在基于 ROI 的分析中，在 SWI 和 T1WI 上确定齿状核、小脑上脚、苍白球和丘脑的被盖的信号强度，以计算齿状核-小脑上脚和苍白球-丘脑比值。采用重复测量方差分析比较基于钆造影剂组与对照组的 SWI、SWI 和 T1WI 信号强度比值。进行 Pearson 相关性分析以确定信号强度比值与变量之间的任何相关性。
与大环类基于钆造影剂和对照组相比，线性基于钆造影剂组的 SWI 和 SWI 的齿状核-小脑上脚和苍白球-丘脑比值均较低（<.05）。大环类基于钆造影剂组与对照组之间的 SWI 和 SWI 比值无显著差异（>.05）。线性基于钆造影剂组的 T1WI 上的齿状核-小脑上脚和苍白球-丘脑比值均高于对照组和大环类基于钆造影剂组（<.05）。SWI 和 SWI 比值与线性基于钆造影剂给药次数之间存在负相关（齿状核-小脑上脚比值：SWI， = -0.43， =.005；SWI， = -0.38， =.011；苍白球-丘脑比值：SWI， = -0.39， =.009；SWI， = -0.33， =.017）。
儿科脑的 SWI 分析显示，在使用线性基于钆的造影剂后，齿状核和苍白球的 SWI 和 SWI 值在统计学上显著降低，但大环类基于钆的造影剂没有。
