Ouyang Minglei, Bao Li
Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
J Magn Reson Imaging. 2025 Jan;61(1):70-82. doi: 10.1002/jmri.29389. Epub 2024 Apr 10.
Over the past few years, a large number of studies have evidenced increased signal intensity in the deep brain nuclei on unenhanced T1-MRI images achieved by the application of gadolinium-based contrast agents (GBCAs). The deposition of gadolinium in the brain, bone, and other tissues following administration of GBCAs has also been confirmed in histological studies in rodents and in necropsy studies in adults and children. Given the distinct physiological characteristics of children, this review focuses on examining the current research on gadolinium deposition in children, particularly studies utilizing novel methods and technologies. Furthermore, the article compares safety research findings of linear GBCAs and macrocyclic GBCAs in children, with the aim of offering clinicians practical guidance based on the most recent research outcomes. LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY: Stage 2.
在过去几年中，大量研究表明，使用钆基造影剂（GBCAs）后，未增强的T1-MRI图像上深部脑核的信号强度增加。在啮齿动物的组织学研究以及成人和儿童的尸检研究中，也证实了给予GBCAs后钆在脑、骨和其他组织中的沉积。鉴于儿童独特的生理特征，本综述着重探讨目前关于儿童钆沉积的研究，特别是利用新方法和技术的研究。此外，本文比较了线性GBCAs和大环GBCAs在儿童中的安全性研究结果，旨在根据最新研究成果为临床医生提供实用指导。证据水平：5 技术疗效：2期。
