Department of Cardiothoracic Surgery, University Medical Centre Groningen, Groningen, The Netherlands
Department of Critical Care, University Medical Centre Groningen, Groningen, The Netherlands.
Open Heart. 2021 Apr;8(1). doi: 10.1136/openhrt-2020-001569.
This study aimed to explore the influence of coronary artery bypass grafting (CABG) on both postoperative cognitive dysfunction and quality of life (QoL) and the association between the two patient-related outcomes.
In a prospective, observational cohort study, patients with elective, isolated CABG were included. Cognitive function was assessed using the Cogstate computerised cognitive test battery preoperatively, 3 days and 6 months after surgery. QoL was measured preoperatively and at 6 months using the RAND-36 questionnaire including the Physical Component Score (PCS) and the Mental Component Score (MCS). Regression analysis, with adjustment for confounders, was used to evaluate the association between postoperative cognitive dysfunction and QoL.
A total of 142 patients were included in the study. Evidence of persistent cognitive dysfunction was observed in 33% of patients after 6 months. At 6 months, the PCS had improved in 59% and decreased in 21% of patients, and the MCS increased in 49% and decreased in 29%. Postoperative cognitive changes were not associated with QoL scores.
Postoperative cognitive dysfunction and decreased QoL are common 6 months after surgery, although cognitive function and QoL were found to have improved in many patients at 6 months of follow-up. Impaired cognitive function is not associated with impaired QoL at 6 months.
NCT03774342.
本研究旨在探讨冠状动脉旁路移植术（CABG）对术后认知功能障碍和生活质量（QoL）的影响，以及这两种患者相关结局之间的关联。
在一项前瞻性、观察性队列研究中，纳入了择期行单纯 CABG 的患者。在术前、术后 3 天和 6 个月使用 Cogstate 计算机认知测试电池评估认知功能。在术前和术后 6 个月使用 RAND-36 问卷（包括生理成分评分[PCS]和心理成分评分[MCS]）测量 QoL。采用回归分析（调整混杂因素）评估术后认知功能障碍与 QoL 之间的关联。
本研究共纳入 142 例患者。术后 6 个月时，33%的患者存在持续的认知功能障碍。6 个月时，59%的患者 PCS 改善，21%的患者 PCS 下降，49%的患者 MCS 增加，29%的患者 MCS 下降。术后认知变化与 QoL 评分无关。
术后认知功能障碍和 QoL 下降在术后 6 个月很常见，但在术后 6 个月的随访中，许多患者的认知功能和 QoL 都有所改善。术后认知功能障碍与 6 个月时的 QoL 受损无关。
NCT03774342。
