Kim Jason Hs, Lam Joseph M
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Pediatrics and Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Drugs Context. 2021 Apr 6;10. doi: 10.7573/dic.2020-12-6. eCollection 2021.
Infantile haemangiomas (IHs) are relatively common benign vascular tumours found in the paediatric population. They have varying sizes and involve different depths in the skin leading to various colours, shapes and textures. Although considered harmless in most cases, they may lead to life-threatening complications or cause permanent disfigurations and organ dysfunction. For problematic IHs, the treatment options include oral and topical beta-blockers, systemic corticosteroids, laser treatment, and surgery. In this narrative review, the treatment options for problematic IH are compared and delivered concisely to facilitate the clinical decisions from practitioners, including those in primary care settings. Oral propranolol is currently considered the first-line intervention for problematic IHs. For superficial lesions, there is robust evidence for the use of topical timolol maleate. Systemic corticosteroids are sometimes used in specific situations such as resistance or contraindications to beta-blockers. Surgical excision can be considered in cases requiring urgent intervention such as airway obstruction; this can be done alongside laser therapies for the removal of residual tissue or when reconstructing areas of deformity. The combination of multiple treatment modalities may lead to a more rapid clinical response.
婴儿血管瘤(IHs)是在儿科人群中发现的相对常见的良性血管肿瘤。它们大小各异,累及皮肤的不同深度,导致各种颜色、形状和质地。尽管在大多数情况下被认为无害,但它们可能导致危及生命的并发症,或造成永久性毁容和器官功能障碍。对于有问题的婴儿血管瘤,治疗选择包括口服和外用β受体阻滞剂、全身用皮质类固醇、激光治疗和手术。在这篇叙述性综述中,对有问题的婴儿血管瘤的治疗选择进行了比较并简要介绍,以方便从业者做出临床决策,包括初级保健机构的从业者。口服普萘洛尔目前被认为是治疗有问题的婴儿血管瘤的一线干预措施。对于浅表病变,有充分证据支持使用外用马来酸噻吗洛尔。全身用皮质类固醇有时用于特定情况,如对β受体阻滞剂耐药或有禁忌证时。在需要紧急干预的情况下,如气道阻塞,可以考虑手术切除;这可以与激光治疗一起进行,以去除残留组织或在重建畸形部位时使用。多种治疗方式的联合使用可能会带来更快的临床反应。